In vitro Study on Biodegradable AZ31 Magnesium Alloy Fibers Reinforced PLGA Composite

doi:10.1016/j.jmst.2013.03.004

J. Mater. Sci. Technol. ›› 2013, Vol. 29 ›› Issue (6): 545-550.DOI: 10.1016/j.jmst.2013.03.004

Previous Articles Next Articles

In vitro Study on Biodegradable AZ31 Magnesium Alloy Fibers Reinforced PLGA Composite

Y.H. Wu¹⁾,N.Li^1,2), Y. Cheng¹⁾, Y.F. Zheng^1,2),Y.Han³⁾

1) Center for Biomedical Materials and Tissue Engineering, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing 100871, China
2) Department of Materials Science and Engineering, College of Engineering, Peking University, Beijing 100871, China
3) State Key Laboratory for Mechanical Behavior of Materials, Xi’an Jiaotong University, Xi’an 710049, China

Received:2012-11-19 Revised:2013-02-25 Online:2013-06-30 Published:2013-05-17
Contact: Y. F. Zheng
Supported by:
National Basic Research Program of China (973 Program) (Grant Nos. 2012CB619102 and 2012CB619103), the State Key Laboratory for Mechanical Behavior of Materials (Grant No. 20111210), the National High Technology Research and Development Program of China (863 Program) (Grant No. 2011AA030103), the Research Fund for the Doctoral Program of Higher Education (Grant No. 20100001110011), the National Natural Science Foundation of China (No. 31170909) and the National Science Fund for Distinguished Young Scholars (Grant No. 51225101).

Abstract

Abstract:

AZ31 magnesium alloy fibers reinforced poly(lactic-co-glycolic acid) (PLGA) composites were prepared and their mechanical property, immersion corrosion behavior and biocompatibility were studied. The tensile test showed that with the addition of AZ31 fibers, the composites had a significant increment in tensile strength and elongation. For the direct cell attachment test, all the cells showed a healthy morphology and spread well on the experimental sample surfaces. The immersion results indicated that pH values of the immersion medium increased with increasing AZ31 fiber contents. All the in vitro experimental results indicated that this new kind of magnesium alloy fibers reinforced PLGA composites show a potential for future biomedical applications.

Key words: Biomaterials, Corrosion, Polymeric composites, AZ31 magnesium ?ber

Y.H. Wu,N.Li, Y. Cheng, Y.F. Zheng,Y.Han. In vitro Study on Biodegradable AZ31 Magnesium Alloy Fibers Reinforced PLGA Composite[J]. J. Mater. Sci. Technol., 2013, 29(6): 545-550.

References

[1] X.N. Gu, Y.F. Zheng, Y. Cheng, S.P. Zhong, T.F. Xi, Biomaterials30 (2009) 484-498.

[2] F. Witte, Acta Biomater. 6 (2010) 1680-1692.

[3] T. Kraus, S.F. Fischerauer, A.C. Hänzi, P.J. Uggowitzer, J.F. Löffler,A.M. Weinberg, Acta Biomater. 8 (2012) 1230-1238.

[4] Q. Peng, Y. Huang, L. Zhou, N. Hort, K.U. Kainer, Biomaterials 31(2010) 398-403.

[5] Y. Xin, T. Hu, P.K. Chu, Acta Biomater. 7 (2011) 1452-1459.

[6] F. Witte, J. Fischer, J. Nellesen, C. Vogt, J. Vogt, T. Donath, F.Beckmann, Acta Biomater. 6 (2010) 1792-1799.

[7] D. Xue, Y. Yun, Z. Tan, Z. Dong, M.J. Schulz, J. Mater. Sci.Technol. 28 (2012) 261-267.

[8] M.P. Staiger, A.M. Pietak, J. Huadmai, G. Dias, Biomaterials 27(2006) 1728-1734.

[9] X.N. Gu, N. Li, Y.F. Zheng, L. Ruan, Mater. Sci. Eng. B 176 (2011)1778-1784.

[10] X.N. Gu, X.H. Xie, N. Li, Y.F. Zheng, L. Qin, Acta Biomater. 8(2012) 2360-2374.

[11] X. Zhang, G. Yuan, L. Mao, J. Niu, W. Ding, Mater. Lett. 66 (2012)209-211.

[12] X. Gu, Y. Zheng, S. Zhong, T. Xi, J. Wang, W. Wang, Biomaterials31 (2010) 1093-1103.

[13] H.S. Brar, J. Wong, M.V. Manuel, J. Mech. Behav. Biomed. Mater.7 (2012) 87-95.

[14] K. Kitazono, E. Sato, K. Kuribayashi, Scripta Mater. 44 (2001)2695-2702.

[15] J.M. Seitz, E. Wulf, P. Freytag, D. Bormann, F.W. Bach, Adv. Eng.Mater. 12 (2010) 1099-1105.

[16] H.F. Sun, C.J. Li, W.B. Fang, Trans. Nonferrous Met. Soc. China 21 (2011) s258es261.

[17] G. Chen, Y. Xia, X. Lu, X. Zhou, F. Zhang, N. Gu, J. Biomed.Mater. Res. Part A 101 (2013) 44-53.

[18] M. Ebrahimian-Hosseinabadi, F. Ashrafizadeh, M. Etemadifar,S.S. Venkatraman, J. Mater. Sci. Technol. 27 (2011) 1105-1112.

[19] S.J. Kim, D.H. Jang, W.H. Park, B.M. Min, Polymer 51 (2010)1320-1327.

[20] F. He, J. Ye, J. Biomed. Mater. Res. Part A 100 (2012) 3239-3250.

[21] H. Li, J. Chang, Compos. Sci. Technol. 65 (2005) 2226-2232.

[22] S.L. Ishaug, G.M. Crane, M.J. Miller, A.W. Yasko, M.J. Yaszemski,A.G. Mikos, J. Biomed. Mater. Res. 36 (1997) 17-28.

[23] Z.L. Mou, L.J. Zhao, Q.A. Zhang, J. Zhang, Z.Q. Zhang, J.Supercrit. Fluids 58 (2011) 398-406.

[24] D.W. Hutmacher, Biomaterials 21 (2000) 2529-2543.

[25] X. Miao, W.K. Lim, X. Huang, Y. Chen, Mater. Lett. 59 (2005)4000-4005.

[26] M. Ngiam, S. Liao, A.J. Patil, Z. Cheng, C.K. Chan, S. Ramakrishna,Bone 45 (2009) 4-16.

[27] G.E. Park, M.A. Pattison, K. Park, T.J. Webster, Biomaterials 26(2005) 3075-3082.

[28] D.P. Link, J. van den Dolder, W.J.F.M. Jurgens, J.G.C. Wolke, J.A.Jansen, Biomaterials 27 (2006) 4941-4947.

[29] Y. Chen, Y. Song, S.X. Zhang, J.N. Li, C.L. Zhao, X.N. Zhang,Biomed. Mater. 6 (2011) 025005.

[30] C.M. Agrawal, R.B. Ray, J. Biomed. Mater. Res. 55 (2001) 141-150.

[31] L. Lu, S.J. Peter, M.D. Lyman, H.L. Lai, S.M. Leite, J.A. Tamada,S. Uyama, J.P. Vacanti, L. Robert, A.G. Mikos, Biomaterials 21(2000) 1837-1845.

[32] C.M. Agrawal, G.G. Niederauer, K.A. Athanasiou, Tissue Eng. 1(1995) 241-252.

In vitro Study on Biodegradable AZ31 Magnesium Alloy Fibers Reinforced PLGA Composite

RichHTML

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments

[1]	Hu Liu, Jie Wei, Junhua Dong, Yiqing Chen, Yumin Wu, Yangtao Zhou, Subedi Dhruba Babu, Wei Ke. Influence of cementite spheroidization on relieving the micro-galvanic effect of ferrite-pearlite steel in acidic chloride environment [J]. J. Mater. Sci. Technol., 2021, 61(0): 234-246.
[2]	Yanxin Qiao, Daokui Xu, Shuo Wang, Yingjie Ma, Jian Chen, Yuxin Wang, Huiling Zhou. Effect of hydrogen charging on microstructural evolution and corrosion behavior of Ti-4Al-2V-1Mo-1Fe alloy [J]. J. Mater. Sci. Technol., 2021, 60(0): 168-176.
[3]	Jiawei Ding, Haitao Wang, En-Hou Han. A multiphysics model for studying transient crevice corrosion of stainless steel [J]. J. Mater. Sci. Technol., 2021, 60(0): 186-196.
[4]	Hongxia Wan, Dongdong Song, Xiaolei Shi, Yong Cai, Tingting Li, Changfeng Chen. Corrosion behavior of Al_0.4CoCu_0.6NiSi_0.2Ti_0.25 high-entropy alloy coating via 3D printing laser cladding in a sulphur environment [J]. J. Mater. Sci. Technol., 2021, 60(0): 197-205.
[5]	Yanhua Zeng, Fenfen Yang, Zongning Chen, Enyu Guo, Minqiang Gao, Xuejian Wang, Huijun Kang, Tongmin Wang. Enhancing mechanical properties and corrosion resistance of nickel-aluminum bronze via hot rolling process [J]. J. Mater. Sci. Technol., 2021, 61(0): 186-196.
[6]	Xian-Zong Wang, Hong-Qiang Fan, Triratna Muneshwar, Ken Cadien, Jing-Li Luo. Balancing the corrosion resistance and through-plane electrical conductivity of Cr coating via oxygen plasma treatment [J]. J. Mater. Sci. Technol., 2021, 61(0): 75-84.
[7]	Lei Liu, Liang Wu, Xiaobo Chen, Deen Sun, Yuan Chen, Gen Zhang, Xingxing Ding, Fusheng Pan. Enhanced protective coatings on Ti-10V-2Fe-3Al alloy through anodizing and post-sealing with layered double hydroxides [J]. J. Mater. Sci. Technol., 2020, 37(0): 104-113.
[8]	Jun Gao, Jibo Tan, Ming Jiao, Xinqiang Wu, Lichen Tang, Yifeng Huang. Role of welding residual strain and ductility dip cracking on corrosion fatigue behavior of Alloy 52/52M dissimilar metal weld in borated and lithiated high-temperature water [J]. J. Mater. Sci. Technol., 2020, 42(0): 163-174.
[9]	Jufeng Huang, Guang-Ling Song, Andrej Atrens, Matthew Dargusch. What activates the Mg surface—A comparison of Mg dissolution mechanisms [J]. J. Mater. Sci. Technol., 2020, 57(0): 204-220.
[10]	Yucheng Ji, Chaofang Dong, Decheng Kong, Xiaogang Li. Design materials based on simulation results of silicon induced segregation at AlSi10Mg interface fabricated by selective laser melting [J]. J. Mater. Sci. Technol., 2020, 46(0): 145-155.
[11]	Yuanjie Zhi, Tao Yang, Dongmei Fu. An improved deep forest model for forecast the outdoor atmospheric corrosion rate of low-alloy steels [J]. J. Mater. Sci. Technol., 2020, 49(0): 202-210.
[12]	Yingdong Zhang, Fusen Yuan, Fuzhou Han, Muhammad Ali, Wenbin Guo, Geping Li, Chengze Liu, Hengfei Gu. The influence of microtexture on the formation mechanism of nodules in Zircaloy-4 alloy tube [J]. J. Mater. Sci. Technol., 2020, 47(0): 68-75.
[13]	Ruoxian Wang, Gaowu Qin, Erlin Zhang. Effect of Cu on Martensite Transformation of CoCrMo alloy for biomedical application [J]. J. Mater. Sci. Technol., 2020, 52(0): 127-135.
[14]	Lijin Dong, Cheng Ma, Qunjia Peng, En-Hou Han, Wei Ke. Microstructure and stress corrosion cracking of a SA508-309L/308L-316L dissimilar metal weld joint in primary pressurized water reactor environment [J]. J. Mater. Sci. Technol., 2020, 40(0): 1-14.
[15]	Yanhui Li, Siwen Wang, Xuewei Wang, Meiling Yin, Wei Zhang. New FeNiCrMo(P, C, B) high-entropy bulk metallic glasses with unusual thermal stability and corrosion resistance [J]. J. Mater. Sci. Technol., 2020, 43(0): 32-39.