Started in 1985 Semimonthly
ISSN 1005-0302
CN 21-1315/TG
Impact factor:6.155

The journal has been awarded the excellent periodical in China, and its articles are covered by SCI, EI, CA, SA, JST, RJ, CSA, MA, EMA, AIA etc., PASCAL web. ISI web of Science,SCOPUS.

  Current Issue
      30 June 2013, Volume 29 Issue 6 Previous Issue    Next Issue
    For Selected: View Abstracts Toggle Thumbnails
    Novel Magnesium Alloys Developed for Biomedical Application: A Review
    Nan Li, Yufeng Zheng
    J. Mater. Sci. Technol., 2013, 29 (6): 489-502.  DOI: 10.1016/j.jmst.2013.02.005
    Abstract   HTML   PDF

    There is an increasing interest in the development of magnesium alloys both for industrial and biomedical applications. Industrial interest in magnesium alloys is based on strong demand of weight reduction of transportation vehicles for better fuel efficiency, so higher strength, and better ductility and corrosion resistance are required. Nevertheless, biomedical magnesium alloys require appropriate mechanical properties, suitable degradation rate in physiological environment, and what is most important, biosafety to human body. Rather than simply apply commercial magnesium alloys to biomedical field, new alloys should be designed from the point of view of nutriology and toxicology. This article provides a review of state-of-the-art of magnesium alloy implants and devices for orthopedic, cardiovascular and tissue engineering applications. Advances in new alloy design, novel structure design and surface modification are overviewed. The factors that influence the corrosion behavior of magnesium alloys are discussed and the strategy in the future development of biomedical magnesium alloys is proposed.

    References | Related Articles | Metrics
    Biodegradable Materials for Bone Repairs: A Review
    Lili Tan, Xiaoming Yu, Peng Wan, Ke Yang
    J. Mater. Sci. Technol., 2013, 29 (6): 503-513.  DOI: 10.1016/j.jmst.2013.03.002
    Abstract   HTML   PDF

    With attractive research and development of biomaterials, more and more opportunities have been brought to the treatments of human tissue repairs. The implant is usually no need to exist in the body accompanied with the recovery or regeneration of the tissue lesions, and the long-term effect of exotic substance to human body should be reduced as lower as possible. For this purpose, biodegradable materials, including polymers, magnesium alloys and ceramics, have attracted much attention for medical applications due to their biodegradable characters in body environment. This paper in turn introduces these three different types of widely studied biodegradable materials as well as their advantages as implants in applications for bone repairs. Relevant history and research progresses are summarized.

    References | Related Articles | Metrics
    Compression Molded Ultra High Molecular Weight Polyethylene- Hydroxyapatite-Aluminum Oxide-Carbon Nanotube Hybrid Composites for Hard Tissue Replacement
    Ankur Gupta, Garima Tripathi, Debrupa Lahiri, Kantesh Balani
    J. Mater. Sci. Technol., 2013, 29 (6): 514-522.  DOI: 10.1016/j.jmst.2013.03.010
    Abstract   HTML   PDF

    Ultra high molecular weight polyethylene (UHMWPE) is widely used for articulating surfaces in total hip and knee replacements. In the present work, UHMWPE based polymer composites were synthesized by synergistic reinforcing of bioactive hydroxyapatite (HA), bioinert aluminum oxide (Al2O3), and carbon nanotubes (CNTs) using compression molding. Phase and microstructural analysis suggests retention of UHMWPE and reinforcing phases in the compression molded composites. Microstructural analysis elicited variation in densification due to the size effect of the reinforcing particles. The hybrid composites exhibited hardness, elastic modulus and toughness comparable to that of UHMWPE. The interfacial effect of reinforcement phases has evinced the effectiveness of Al2O3 over HA and CNT reinforcements, depicting synergistic enhancement in hardness and elastic modulus. Weak interfacial bonding of polymer matrix with HA and CNT requires utilization of coupling agents to achieve enhanced mechanical properties without deteriorating cytocompatible properties.

     
    References | Related Articles | Metrics
    Fabrication of Titanium/Fluorapatite Composites and In Vitro Behavior in Simulated Body Fluid
    Hezhou Ye, Xing Yang Liu, Hanping Hong
    J. Mater. Sci. Technol., 2013, 29 (6): 523-532.  DOI: 10.1016/j.jmst.2013.01.013
    Abstract   HTML   PDF

    Titanium/fluorapatite (Ti/FA) composites with various FA additions were fabricated by powder metallurgy. The decomposition of FA during sintering was accelerated by the presence of Ti. The main reaction products of FA and Ti were identified as CaO, Ti phosphides, and CaTiO3. The addition of FA significantly inhibited the densification of Ti. The in vitro bioactivity of the composites was evaluated in a simulated body fluid (SBF). After immersion into the SBF, all the Ti/FA composites induced nucleation and growth of bone-like carbonated apatite on the surface. Co-precipitation of CaCO3 and Mg(OH)2 was also detected on the surface of the composite with high FA addition at an early stage of immersion. Furthermore, the release of fluorine ions from the composite was confirmed, which could promote bone regeneration and retard the formation of caries in the biological environment. The in vitro behavior was attributed to multiple factors, including the surface conditions and the constituents of the composite. The results demonstrated that the Ti/FA composites were bioactive in nature even with a low FA addition and they could introduce the benefit of fluorine ions in the service.

    References | Related Articles | Metrics
    Ionic Liquids Assisted Synthesis of ZnO Nanostructures: Controlled Size, Morphology and Antibacterial Properties
    R. Rajiv Gandhi, S. Gowri, J. Suresh, M. Sundrarajan
    J. Mater. Sci. Technol., 2013, 29 (6): 533-538.  DOI: 10.1016/j.jmst.2013.03.007
    Abstract   HTML   PDF

    Systematic analysis about the exploitation of imidazolium based ionic liquids (ILs), [BMIM] BF4 [IL1], [EMIM] BF4 [IL2] and [BMIM] PF6 [IL3] as the morphological template on the basic sol–gel method adopted synthesis of nanostructured zinc oxide (ZnO) is presented. X-ray diffraction (XRD), particle size analysis (PSA) and scanning electron microscopy (SEM) have been employed for the characterization of structure and morphology of the synthesized ZnO particles. Well-defined capsule like shaped morphology with lower nanosize is observed for the ZnO nanoparticles with IL1 than those with IL2 and IL3. This confirms that IL1 served as an effective templating material due to their unique properties. Especially the effective aggregation of ZnO particles with a self-organized frame of IL1 was the essential factor to produce the lower nanosized ZnO with capsule shaped structure. The synthesized ZnO samples with IL2 and IL3 fabricated the flake like shaped and rod like shaped morphologies in the range of nanoscale. The formed ZnO nanoparticles with IL2 exhibit higher nanosize than the ZnO nanoparticles produced by IL1, owing to shorter length of alkyl group in its cation which restricts steric effect and permits the nanoparticles to grow longer. Even though IL3 produced the discrete ZnO nanorods, the hydrophobic nature of IL3 created the higher nanosize than the ZnO nanoparticles formed by other two ionic liquids. Antibacterial properties of the synthesized ZnO nanostructures were investigated against Staphylococcus aureus (gram positive) and Escherichia coli (gram negative) bacteria by Agar diffusion test method. Microbial experiments indicate that the synthesized ZnO samples show a wide spectrum of antimicrobial activities and performed better against S. aureus than E. coli with the same concentration of ZnO.

    References | Related Articles | Metrics
    Magnesium Alloy for Repair of Lateral Tibial Plateau Defect in Minipig Model
    Qiang Zhang, Xiao Lin, Zhengrong Qi, Lili Tan, Ke Yang, Zhuangqi Hu, Yan Wang
    J. Mater. Sci. Technol., 2013, 29 (6): 539-544.  DOI: 10.1016/j.jmst.2013.03.003
    Abstract   HTML   PDF

    Bone graft substitutes are widely-studied as alternatives to bone grafts in the clinic. The currently available products are mostly ceramics and polymers. Considerable progress has been made in the study of the biodegradable magnesium alloys, which possess the necessary attributions of a suitable substitute, including an excellent mechanical property. In the present study, a minipig model of a lateral tibial plateau defect was used to evaluate the effectiveness of a magnesium alloy in the repair of a critical-sized defect. The micro-arc oxidation (MAO)-coated ZK60 alloy tablets and medical-grade calcium sulfate pellets were used as the test and control materials, respectively. Bone morphology was monitored by computed tomography after the implantation for 2 and 4 months. It was found that the bone morphology in minipigs following magnesium treatment was similar to that of the normal bone, whereas an abnormal and concave morphology was displayed following the calcium sulfate treatment. The average bone healing rate for the magnesium-treated defects was higher than that of the calcium sulfate-treated defects at the first 4 months following the implantation. Overall, magnesium treatment appeared to improve the defect repair as compared with the calcium sulfate treatment. Thus, the MAO-coated ZK60 alloy appears to be a useful biocompatible bone graft substitute, and further research on its biological activity in vivo is needed.

    References | Related Articles | Metrics
    In vitro Study on Biodegradable AZ31 Magnesium Alloy Fibers Reinforced PLGA Composite
    Y.H. Wu,N.Li, Y. Cheng, Y.F. Zheng,Y.Han
    J. Mater. Sci. Technol., 2013, 29 (6): 545-550.  DOI: 10.1016/j.jmst.2013.03.004
    Abstract   HTML   PDF

    AZ31 magnesium alloy fibers reinforced poly(lactic-co-glycolic acid) (PLGA) composites were prepared and their mechanical property, immersion corrosion behavior and biocompatibility were studied. The tensile test showed that with the addition of AZ31 fibers, the composites had a significant increment in tensile strength and elongation. For the direct cell attachment test, all the cells showed a healthy morphology and spread well on the experimental sample surfaces. The immersion results indicated that pH values of the immersion medium increased with increasing AZ31 fiber contents. All the in vitro experimental results indicated that this new kind of magnesium alloy fibers reinforced PLGA composites show a potential for future biomedical applications.

    References | Related Articles | Metrics
    Compressive Mechanical Characteristics of Multi-layered Gradient Hydroxyapatite Reinforced Poly (Vinyl Alcohol) Gel Biomaterial
    Yusong Pan, Qianqian Shen, Chengling Pan, Jing Wang
    J. Mater. Sci. Technol., 2013, 29 (6): 551-556.  DOI: 10.1016/j.jmst.2013.03.011
    Abstract   HTML   PDF

    Functional gradient materials provided us a new concept for artificial articular cartilage design with gradient component and gradient structure where one side of the material is high free water content thereby providing excellent lubrication function and the opposite side of the material is high hydroxyapatite content, thereby improving the bioactivity of the material and stimulating cell growth. The goal of the present study was to develop a multi-layered gradient HA/PVA gel biocomposites through layer-by-layer casting method combing with freeze/thaw cycle technology. The various influence factors on the compressive strength and modulus of the multi-layered gradient biocomposites were investigated. The results showed that the compressive mechanical characteristics of the biocomposites were similar to that of natural articular cartilage. Both the compressive strength and modulus of the multi-layered gradient HA/PVA gel biocomposites increased exponentially with the rise of compressive strain ratio. Both the compressive strength and average compressive modulus of the biocomposites improved with the rise of freeze/thaw cycle times and total concentration of HA particles in the biocomposites, but they showed decreasing tendency with the rise of HA concentration difference between adjacent layers.

     
    References | Related Articles | Metrics
    Dip Coating of Nano Hydroxyapatite on Titanium Alloy with Plasma Assisted γ-Alumina Buffer Layer: A Novel Coating Approach
    M. Khalid, M. Mujahid, A. Nusair Khan, R.S. Rawat
    J. Mater. Sci. Technol., 2013, 29 (6): 557-564.  DOI: 10.1016/j.jmst.2013.02.003
    Abstract   HTML   PDF

    This paper reported a novel coating approach to deposit a thin, crack free and nano-structured hydroxyapatite (HA) film on Ti6Al4V alloy with Al2O3 buffer layer for biomedical implants. The Al2O3 buffer layer was deposited by plasma spraying while the HA top layer was applied by dip coating technique. The X-ray diffraction (XRD) and Raman reflections of alumina buffer layer showed α- to γ-Al2O3 phase transformation; and the fractographic analysis of the sample revealed the formation of columnar grains in well melted splats. The bonding strength between Al2O3 coating and Ti6Al4V substrate was estimated to be about 40 MPa. The presence of dip coated HA layer was confirmed using XRD, scanning electron microscopy (SEM) and energy dispersive X-ray spectroscopy (EDX) analysis. The SEM images exhibited that HA top layer enveloped homogenously the troughs and crests of the underneath rough (Ra = 2.91 μm) Al2O3 surface. It is believed that the novel coating approach adopted might render the implant suitable for rapid cement-less fixation as well as biocompatible for longer periods.

    References | Related Articles | Metrics
    Microstructural Development of Ti-B Alloyed Layer for Hard Tissue Applications
    A. Miklaszewski, M.U. Jurczyk, M. Jurczyk
    J. Mater. Sci. Technol., 2013, 29 (6): 565-572.  DOI: 10.1016/j.jmst.2013.02.014
    Abstract   HTML   PDF

    Microstructural development was analyzed due to the effect of different sizes of precursor powders during surface plasma alloying modification on titanium surface. Ti–B nano and micropowders with 10 wt% B were deposited onto microcrystalline titanium substrate by plasma alloying. As a result, modified surface layer composed of Ti matrix and TiB borides was obtained. The type of the powder precursor influenced recasting process, possible occurrence of porosity and finally the obtained properties and microstructure of the surface layer. Different morphologies and sizes of TiB phase from micro, submicro to even nano increased the hardness and wear resistance of the obtained surface layers. Discussed results referred to a strong TiB precipitation dispersion provided by a fine elements homogenization during mechanical alloying process. Additionally, results of in vitro test with normal human osteoblast cells revealed proper cellular adhesion to modified surfaces. Scanning electron microscopy observation revealed the influence of gas pore size on culturing osteoblast colony. The proposed surface alloying was an effective method of producing TiB phase dispersed in α-Ti matrix with high hardness, good corrosion resistance and good cytocompatibility. Results confirmed that different types of the precursor powders influenced the properties of the surface layer. TiB phase dispersed in α-Ti matrix layer can offer new structural and biofunctional properties for innovative products in hard tissue applications.

    References | Related Articles | Metrics
    Thermo-mechanical, Wear and Fracture Behavior of High-density Polyethylene/Hydroxyapatite Nano Composite for Biomedical Applications: Effect of Accelerated Ageing
    H. Fouad, R. Elleithy, Othman Y. Alothman
    J. Mater. Sci. Technol., 2013, 29 (6): 573-581.  DOI: 10.1016/j.jmst.2013.03.020
    Abstract   HTML   PDF

    The objective of this work is to demonstrate how the viscoelastic, thermal, rheological, hardness, wear resistance and fracture behavior of bioinert high-density polyethylene (HDPE) can be changed by the addition of hydroxyapatite (HAP) nano particles. Also the effects of accelerated thermal ageing on the composite properties have been investigated. Different weight fractions of HAP nano particles up to 30 wt% have been incorporated in HDPE matrix by using melt blending in co-rotating intermeshing twin screw extruder. The fracture toughness results showed a remarkable decrease in proportion to the HAP content. The differential scanning calorimetry results indicated that the melting temperature and crystallinity were affected by the addition of HAP nano particles into the matrix. The complex viscosity increased as the percentage of HAP increased due to the restriction of the molecular mobility. The dynamic mechanical analysis results revealed that higher storage modulus (8.3 × 1011 Pa) could be obtained in the developed HDPE/HAP in 30 wt% compared to neat HDPE (5.1 × 1011 Pa). Finally, the hardness and wear resistance of HDPE were improved significantly due to the addition of HAP nano particles. The changes in the HDPE and its nano composite properties due to ageing showed that the HDPE and its nano composites crystallinity increased while the fracture toughness, hardness, wear resistance, storage and loss modulus decreased.

    References | Related Articles | Metrics
    Influence of Fluoride Content of Artificial Saliva on Metal Release from 17-4 PH Stainless Steel Foam for Dental Implant Applications
    Ilven Mutlu, Enver Okta
    J. Mater. Sci. Technol., 2013, 29 (6): 582-588.  DOI: 10.1016/j.jmst.2013.03.006
    Abstract   HTML   PDF

    Highly porous 17-4 PH stainless steel foam for implant applications was produced by space holder technique. Metal release and weight loss from 17-4 PH stainless steel foams were investigated in fluoride added artificial saliva environment by static immersion test. An inductively coupled plasma-mass spectrometer was employed to measure the concentrations of various metal ions. Effects of fluoride content of artificial saliva on metal release and weight loss from the steel foams were investigated. Effects of immersion time, pH value and process parameters on the weight loss and metal release were determined. Pore morphology, pore size and mechanical properties of the 17-4 PH stainless steel foams were also characterized.

    References | Related Articles | Metrics
ISSN: 1005-0302
CN: 21-1315/TG
Home
About JMST
Privacy Statement
Terms & Conditions
Editorial Office: Journal of Materials Science & Technology , 72 Wenhua Rd.,
Shenyang 110016, China
Tel: +86-24-83978208
E-mail:JMST@imr.ac.cn

Copyright © 2016 JMST, All Rights Reserved.