J. Mater. Sci. Technol. ›› 2020, Vol. 39: 39-47.DOI: 10.1016/j.jmst.2018.12.017
• Research Article • Previous Articles Next Articles
Shanshan Chena1, Bin Zhangb1, Bin Zhanggchuna, Hao Lina, Hui Yanga, Feng Zhenga, Ming Chenb*(), Ke Yanga*()
Received:
2018-08-21
Revised:
2018-10-31
Accepted:
2018-11-23
Published:
2020-02-15
Online:
2020-03-11
Contact:
Chen Ming,Yang Ke
About author:
1 These authors contributed equally to this work.
Shanshan Chen, Bin Zhang, Bin Zhanggchun, Hao Lin, Hui Yang, Feng Zheng, Ming Chen, Ke Yang. Assessment of structure integrity, corrosion behavior and microstructure change of AZ31B stent in porcine coronary arteries[J]. J. Mater. Sci. Technol., 2020, 39: 39-47.
Fig. 1. Configurations of Mg alloy stent: (a) original configuration, (b) after premounted onto the balloon, (c) drug release curve, (d) morphology after 28 days immersing.
Endpoint | Lumen area (mm2) | Internal elastic lamina area (mm2) | Neointimal area (mm2) |
---|---|---|---|
1-month | 3.63 ± 1.07 | 4.51 ± 1.18 | 0.85 ± 0.36 |
3-month | 2.79 ± 0.66 | 3.80 ± 0.72 | 1.01 ± 0.21 |
6-month | 2.93 ± 0.18 | 4.27 ± 0.98 | 1.33 ± 0.33 |
Table 1 Lumen properties at different implantation times obtained by OCT analysis (n = 2).
Endpoint | Lumen area (mm2) | Internal elastic lamina area (mm2) | Neointimal area (mm2) |
---|---|---|---|
1-month | 3.63 ± 1.07 | 4.51 ± 1.18 | 0.85 ± 0.36 |
3-month | 2.79 ± 0.66 | 3.80 ± 0.72 | 1.01 ± 0.21 |
6-month | 2.93 ± 0.18 | 4.27 ± 0.98 | 1.33 ± 0.33 |
Fig. 2. Stenosis degree followed coronary stenting were severe generally. (a-1), (b-1), (c-1) were the QCA imaging of AZ31B stents implanted for 1, 3 and 6 months. Three AZ31B stents implanted into coronary artery. Positions of stents were indicated by yellow marks. As long with implanting period, the degree of stenosis became severe. In-stent stenosis rate was almost 40%-50% at most narrow section. (a-2), (b-2), (c-2) were the OCT imaging of stents implanted for 1, 3 and 6 months. The neointimal thickness and expansion uniformity of the stent were exhibited. The neointimal proliferation degree had little change as vessel stenting prolonged.
Fig. 3. Neointima morphologies after implantation of AZ31B stents in porcine coronary arteries characterized by SEM: (a) 1-month implantation; (b) 3-month implantation; (c) 6-month implantation; (d) 1-month implantation; (e) 3-month implantation; (f) 6-month implantation.
Fig. 4. Mesh structures of AZ31B stents after implantation for 2 days (a), 1 month (b), 3 months (c) and 6 months (d). In the HRTXRT imaging, the Mg alloy substrate shows as green color and corrosion product shows as blue color pointed by red arrows. The color difference is attributed to the density difference of substances.
Fig. 5. Fracture evolution on AZ31B stent characterized by HRTXRT after implantation for 1 month (a) and 3 months (b). Crack initiating crowed by a red circle in (a); Crack propagation and fractured by a red circle in (b).
Fig. 7. The initial microstructure of a stent unit without deformation and implantation (a, b), and microstructures after implantations for 1 month (c, d) and 3 months (e, f). A lot of twins were found on the stent strut after deformation and implantation, and the twin numbers became larger as long with the implantation went on. At the meanwhile, the grain size became smaller. Degradation products were highlighted by red dotted line. Degradation began from the external to the internal of the stent matrix.
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