Surface modification of titanium implant for repairing/improving microenvironment of bone injury and promoting osseointegration

doi:10.1016/j.jmst.2022.09.044

Abstract

Abstract: Bone injury and implantation operation are often accompanied by microenvironment damage of bone tissue, which seriously affects the process of osseointegration of implants, especially for titanium (Ti)-based bioinert materials. Thus, repairing or improving the microenvironment of damaged bone tissue is of great significance for bone rescue, reconstruction, and regeneration, which is still a major medical challenge. Oxidative stress (OS) and oxygen (O₂) deficiency are considered to be specific physiological signals of the bone-injury microenvironment. From the above background, a coating consisting of manganese dioxide (MnO₂) nanoenzyme and strontium (Sr) ions was fabricated on the surface of the Ti implant via a one-step hydrothermal treatment. MnO₂ nanoenzyme presented in the coating alleviated OS and O₂ deficiency at the injury site by catalyzing the decomposition of abundant endogenous H₂O₂ around the modified Ti implants into O₂. In addition, Sr ions were released from the surface of the implant at a certain rate in a body-fluid environment, further promoting the adhesion, growth, and osteogenic differentiation of mesenchymal stem cells. More importantly, a Sprague Dawley rat femur model demonstrated that the modified Ti implant showed significant potential to accelerate bone tissue reconstruction in vivo. In summary, the present system provides a new idea for the treatment of bone injury and the development of new orthopedic implants.

Key words: Ti and its alloys, Osseointegration, Microenviroment, Nanoenzyme, Sr

Yao Ding, Bailong Tao, Ruichen Ma, Xin Zhao, Peng Liu, Kaiyong Cai. Surface modification of titanium implant for repairing/improving microenvironment of bone injury and promoting osseointegration[J]. J. Mater. Sci. Technol., 2023, 143: 1-11.

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