Fe3O4-rhodamine 6G nanoparticles: An iron enhanced pH sensitive multimodal probe for fluorescence and magnetic resonance imaging of tumor cell

doi:10.1016/j.jmst.2023.03.022

Abstract

Abstract: The accurate diagnosis of tumor at the early stage depends on efficient medical imaging methods using probes with high sensitivity to the environment of tumor cells. For this purpose, we design the Fe₃O₄-rhodamine 6 G (Rh6G) nanoparticles (NPs) as a kind of dual-mode probe for fluorescence and magnetic resonance imaging (MRI). The Fe₃O₄-Rh6G NPs are demonstrated to be Fe³⁺ enhanced and pH-sensitive fluorescent agents, and the strongest fluorescence performance occurs under the pH value of 3. Cytotoxicity assessment in HeLa cells proves the good biocompatibility and low toxicity of the Fe₃O₄-Rh6G NPs. The consequent fluorescence experiments in tumor cells show good imaging contrast, which is contributed by both the Fe³⁺ released from Fe₃O₄ and the acid environment of tumor cells. Moreover, the Fe₃O₄-Rh6G NPs are superparamagnetic and have a strong MRI T₂ contrast effect. According to the performance in fluorescence and MRI tests, the Fe₃O₄-Rh6G NPs are potential dual-mode probes for MRI contrast agents and fluorescence probes with high biocompatibility for early-stage tumor detection.

Key words: Fe₃O₄ nanoparticles, Rhodamine 6G, Fluorescence, Magnetic resonance imaging

Kai Wang, Jian Wang, Xiaoguang Xu, Mayifei Rong, Liying Lu, Xuemei Zhao, Yining Wang, Yong Jiang. Fe₃O₄-rhodamine 6G nanoparticles: An iron enhanced pH sensitive multimodal probe for fluorescence and magnetic resonance imaging of tumor cell[J]. J. Mater. Sci. Technol., 2023, 160: 128-138.

References

[1] R.L. Siegel, K.D. Miller, H.E. Fuchs, A. Jemal, CA-Cancer J. Clin. 71(2021) 7-33.
[2] R. Weissleder, Science 312 (2006) 1168-1171.
[3] Z. Zhou, Z.R. Lu, Adv. Drug Delivery Rev. 113(2017) 24-48.
[4] M.J. Trujillo, J. Chen, J.M. Rubin, J. Gao, Clin. Imaging 78 (2021) 22-34.
[5] A. Hatzor, P. Weiss, Science 291 (2001) 1019-1020.
[6] J. Yu, H.N.Y.Nguyen, W. Steenbergen, K.Kim, J. Nucl. Med. 59(2018) 1202-1207.
[7] H. Wei, A. Wi ´sniowska, J. Fan, P. Harvey, Y. Li, V. Wu, E.C. Hansen, J. Zhang, M.G. Kaul, A.M. Frey, Proc. Natl. Acad. Sci. 118(2021) e2102340118.
[8] J. Yu, F. Zhao, W.L. Gao, X. Yang, Y.M. Ju, L.Y. Zhao, W.S. Guo, J. Xie, X.J. Liang, X.Y. Tao, ACS Nano 13 (2019) 10 0 02-10 014.
[9] K. Wang, L.N. Li, X.G. Xu, L.Y. Lu, J. Wang, S.Y. Wang, Y.N. Wang, Z.Y. Jin, J.Z. Zhang, Y. Jiang, ACS Appl. Mater. Interfaces 11 (2019) 10452-10461.
[10] B. Wu, K. Deng, S.T. Lu, C.J. Zhang, Y.W. Ao, H. Wang, H. Mei, C.X. Wang, H. Xu, B. Hu, Biomaterials 268 (2021) 120531.
[11] Z.Y. Shen, A.G. Wu, X.Y. Chen, Mol. Pharmaceutics 14 (2017) 1352-1364.
[12] D.L. Liu, J.J. Li, C.B. Wang, L. An, J.M. Lin, Q.W. Tian, S.P. Yang, Nanomed.-Nanotechnol. Biol. Med. 32(2021) 102335.
[13] A.R. Chowdhuri, D. Bhattacharya, S.K. Sahu, Dalton Trans. 45(2016) 2963-2973.
[14] S.Y. Yu, X.C. Gao, H. Baigude, X. Hai, R.F. Zhang, X.L. Gao, B.B. Shen, Z. Li, Z.B. Tan, H.Q. Su, ACS Appl. Mater. Interfaces 7 (2015) 5089-5096.
[15] Q.L. Hu, L.S. Wang, N.N. Yu, Z.F. Zhang, X. Zheng, X.M. Hu, Rare Metals 39 (2020) 1333-1340.
[16] W.S. Wang, F.F. Li, S.B. Li, Y. Hu, M.R. Xu, Y.Y. Zhang, M.I. Khan, S.Z. Wang, M. Wu, W.P. Ding, B.S. Qiu, J. Mater. Sci.Technol. 81(2021) 77-87.
[17] E. Kozenkova, K. Levada, M.V. Efremova, A. Omelyanchik, Y.A. Nalench, A.S. Garanina, S. Pshenichnikov, D.G. Zhukov, O. Lunov, M. Lunova, Nanoma-terials 10 (2020) 1646.
[18] Z.Y. Wang, Y.M. Ju, Z. Ali, H. Yin, F.G. Sheng, J. Lin, B.D. Wang, Y.L. Hou, Nat. Commun. 10(2019) 4418.
[19] S. Tong, C.A. Quinto, L.L. Zhang, P. Mohindra, G. Bao, ACS Nano 11 (2017) 6 808-6 816.
[20] J. Li, Z.Q. Feng, N. Gu, F. Yang, J. Mater. Sci.Technol. 63(2021) 124-132.
[21] S.K. Zhou, T. Yin, Q.S. Zou, K.L. Zhang, G. Gao, J.G. Shapter, P. Huang, Q. Fu, Sci. Rep. 7(2017) 42793.
[22] S. Caspani, R. Magalhães, J.P. Araújo, C.T. Sousa, Materials (Basel) 13(2020) 2586.
[23] K. Wang, X.G. Xu, Y.L. Ma, C.R. Sheng, L.N. Li, L.Y. Lu, J. Wang, Y.N. Wang, Y. Jiang, Rare Metals 40 (2021) 2486-2493.
[24] B. Li, T.T. Gong, N.N. Xu, F.Z. Cui, B.Y. Yuan, Q.H. Yuan, H.Z. Sun, L. Wang, J.H. Liu, Small 16 (2020) 2003969.
[25] M. Qin, M.J. Xu, L.L. Niu, Y.Z. Cheng, X.L. Niu, J.L. Kong, X.M. Zhang, Y. Wei, D. Huang, Front. Mater. Sci. 15(2021) 36-53.
[26] C.Y. Li, G.C. Chen, Y.J. Zhang, F. Wu, Q.B. Wang, J. Am. Chem.Soc. 142(2020) 14789-14804.
[27] W.X. Du, T.Z. Liu, F.F. Xue, Y. Chen, Q. Chen, Y. Luo, X.J. Cai, M. Ma, H.R. Chen, Chem. Eng. J. 379(2020) 122251.
[28] P. Swietach, R.D.Vaughan-Jones, A.L. Harris, A. Hulikova, Philos. Trans. R. Soc. B-Biol. Sci. 369(2014) 20130099.
[29] F.A. Gallagher, M.I. Kettunen, S.E. Day, D.E. Hu, J.H. Ardenkjær-Larsen, R. Zandt, P.R. Jensen, M. Karlsson, K. Golman, M.H. Lerche, Nature 453 (2008) 940-943.
[30] S. Granja, D. Tavares-Valente, O. Queiros, F. Baltazar, Semin. Cancer Biol. 43(2017) 17-34.
[31] M.L. Pei, X. Jia, G.P. Li, P. Liu, Mol. Pharm. 16(2018) 227-237.
[32] F. Deng, D.S. Sun, S.X. Yang, W. Huang, C.F. Huang, Z.C. Xu, L.M. Liu, Spectroc. Acta Pt. A-Molec.Biomolec. Spectr. 268(2022) 120662.
[33] M. Dükkancı, Chem. Biochem. Eng. Q. 35(2021) 17-29.
[34] F.M. Zehentbauer, C. Moretto, R. Stephen, T. Thevar, J.R. Gilchrist, D. Pokrajac, K.L. Richard, J. Kiefer, Spectroc, Acta Pt. A-Molec.Biomolec. Spectr. 121(2014) 147-151.
[35] B.D. Wang, J. Hai, Z.C. Liu, Q. Wang, Z.Y. Yang, S.H. Sun, Angew. Chem.-Int. Edit. 122(2010) 46 80-46 83.
[36] Y.K. Cui, Y. Li, Y.R. Liu, D.H. Shang, Y. Liu, L.B. Xie, S.H. Zhan, W.P. Hu, Chem. Commun. 58(2022) 4251-4254.
[37] Q.P. Diao, H. Guo, Z.W. Yang, W.W. Luo, T.C. Li, D.Y. Hou, Anal. Methods 11 (2019) 794-799.
[38] M. Saleem, R. Abdullah, A. Ali, B.J. Park, E.H. Choi, I.S. Hong, K.H. Lee, Bioorg. Med. Chem. 22(2014) 2045-2051.
[39] S. Bae, J. Tae, Tetrahedron Lett. 48(2007) 5389-5392.
[40] P. Guo, L.J. Liu, Q. Shi, C.Y. Yin, X.F. Shi, J. Mol. Struct. 1130(2017) 150-155.
[41] M. Di Paolo, F.M. Boubeta, J. Alday, M.M. Torino, P.F. Aramendia, S.A. Suarez, M.L. Bossi, J. Photochem. Photobiol.A-Chem. 384(2019) 112011.
[42] H.W. Rong, T. Gao, Y. Zheng, L.W. Li, D.K. Xu, X.F. Zhang, Y.L. Hou, M. Yan, J. Mater. Sci.Technol. 84(2021) 116-123.
[43] Y.S. Kwon, K.B. Choi, H. Lim, S. Lee, J.J. Lee, Jpn. J. Appl. Phys. 57 (2018) 06HE03.
[44] G.N. Wang, K. Qian, X.F. Mei, Nanoscale 10 (2018) 10467-10478.
[45] J. Liu, M.H. Tang, Y.H. Zhou, Y.J. Long, Y. Cheng, H.Z. Zheng, RSC Adv. 10(2020) 6919-6926.
[46] C.Y. Lin, M.J. Shieh, Bioconjugate Chem. 29(2018) 1384-1398.
[47] M.J. Molaei, E. Salimi, Mater. Chem. Phys. (2022) 126361.
[48] Q. Zhang, T. Yin, G. Gao, J.G. Shapter, W.E. Lai, P. Huang, W. Qi, J. Song, D.X. Cui, ACS Appl. Mater. Interfaces 9 (2017) 17777-17785.
[49] X. Zhang, Y. Shiraishi, T. Hirai, Org. Lett. 9(2007) 5039-5042.
[50] S.F. Si, C.H. Li, X. Wang, D.P. Yu, Q. Peng, Y.D. Li, Cryst. Growth Des. 5(2005) 391-393.
[51] A. Schoenberg, R. Heck, J. Org. Chem. 39(1974) 3327-3331.
[52] T. Wang, L.H. Zeng, D.L. Li, Appl. Spectrosc. Rev. 52(2017) 883-908.
[53] S. Bakkialakshmi, T. Menaka, J. Mol. Liq. 158(2011) 117-123.
[54] M. Fleet, Acta Crystallogr. Sect. C-Cryst. Struct. Commun. 40(1984) 1491-1493.
[55] X. Wang, X.J. Liu, C.W. Xiao, H. Zhao, M.Y. Zhang, N.N. Zheng, W.Y. Kong, L. Zhang, H.K. Yuan, L.J. Zhang, J. Lu, Mesoporous Mater. 297(2020) 110041.
[56] C. Scialabba, R. Puleio, D. Peddis, G. Varvaro, P. Calandra, G. Cassata, L. Cicero, M. Licciardi, G. Giammona, Nano Res. 10(2017) 3212-3227.

Fe₃O₄-rhodamine 6G nanoparticles: An iron enhanced pH sensitive multimodal probe for fluorescence and magnetic resonance imaging of tumor cell

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