J. Mater. Sci. Technol. ›› 2019, Vol. 35 ›› Issue (11): 2485-2493.DOI: 10.1016/j.jmst.2019.07.030

• Orginal Article • Previous Articles     Next Articles

Wüstite-type Fe0.78Mn0.22O nanocubes: A new class for high-sensitive T2-weighted magnetic resonance imaging agent

Huawei Ronga, Haihua Hua, Jian Zhangc**(), Jianjun Wangab, Mu Zhanga, Gaowu Qinab, Yanhui Zhanga**(), Xuefeng Zhangac*()   

  1. aKey Laboratory for Anisotropy and Texture of Materials (MOE), School of Materials Science and Engineering, Northeastern University, Shenyang, 110819, China
    bShenyang Northeastern Institute of Metal Materials Co., Ltd, Shenyang, 110108, China
    cInstitute of Advanced Magnetic Materials, Hangzhou Dianzi University, Hangzhou, 310012, China
  • Received:2019-02-28 Revised:2019-04-07 Accepted:2019-04-26 Online:2019-11-05 Published:2019-10-21
  • Contact: Zhang Jian,Zhang Yanhui,Zhang Xuefeng

Abstract:

Wüstite-type Fe0.78Mn0.22O nanocubes, with a uniform size of ~10 nm in edge length, have been synthesized by thermal-decomposition approach. The nanocubes exhibited superparamagnetic properties at room temperature, associated with a magnetization of 12.6 emu/g. These Fe0.78Mn0.22O nanocubes present transversal (r2) and longitudinal (r1) relaxivities of 325.9 and 0.518 mM-1 s-1 at 7 T for water protons. The ratio of the r2/r1 (629.2) ranks them being the highest sensitivity (r2/r1) comparable to currently reported T2-weighted magnetic resonance imaging (MRI) agents. Meanwhile, the Fe0.78Mn0.22O nanocubes were functionalized and demonstrated to be biocompatible when attached to the surface of mesenchymal stem cells, therefore showing the promise as a new class of MRI agents in clinic applications.

Key words: Magnetic resonance imaging (MRI), Superparamagnetism, FeMn oxides, Nanocubes