Ultra-small MoS2 nanodots-incorporated mesoporous silica nanospheres for pH-sensitive drug delivery and CT imaging

doi:10.1016/j.jmst.2020.03.019

Abstract

Abstract:

Functionalization of mesoporous silica spheres with well-dispersed and ultra-small nanodots to exert their synergistic effects for biomedical applications has been considered to be an urgent challenge. Herein, homogeneously incorporation of ultra-small and monodispersed MoS₂ nanodots in the mesoporous silica nanospheres (MSN) was achieved by a facile one-step solvothermal reaction. The as-synthesized UsMSND@MSN possessed uniform size (～115 nm) and favorable biocompatibility inherited from MSN. The dispersed UsMSND within MSN could act as anchoring sites for aromatic anti-cancer drug DOX loading, and consequently achieved pH-responsive release based on the special π-π/electrostatic interactions with the DOX molecules. More importantly, the well-dispersed UsMSND in MSN could function as the non-toxic contrast agent for the sensitive in vivo CT imaging in various tumors including breast cancer and glioma with different sections. This work promises a good strategy for dispersed incorporation of UsMSND into MSN as an excellent pH-responsive platform for simultaneous cancer imaging and therapy.

Key words: Mesoporous silica nanospheres, MoS₂ nanodots, pH-responsive, CT imaging, Drug delivery

Leilei Chen, Jun Xu, Yi Wang, Rongqin Huang. Ultra-small MoS₂ nanodots-incorporated mesoporous silica nanospheres for pH-sensitive drug delivery and CT imaging[J]. J. Mater. Sci. Technol., 2021, 63: 91-96.

Figures/Tables 6

Scheme 1. Schematic illustration of the ultra-small MoS2 nanodots-incorporated mesoporous silica nanospheres for pH-sensitive drug delivery and CT imaging.

Fig. 1. (A) TEM and (B) STEM images of UsMSND@MSN (the inset is the magnified TEM image of individual UsMSND@MSN nanoparticles). (C) TEM and (D) HRTEM images of pure UsMSND (silica-extracted sample) (the inset shows the lattices of individual UsMSND).

Fig. 2. (A) Fluorescence spectra of DOX solution before and after loading in UsMSND@MSN. (B) Cumulative release profiles of DOX from UsMSND@MSN at different pH. (C) HU values and corresponding CT images (insets) of PEGylated UsMSND@MSN solutions with different concentrations.

Fig. 3. Confocal microscopy images of MCF-7 cells incubated with DOX-UsMSND@MSN for different time periods. BF: bright field images. Red: DOX. Green: Lysotracker-stained acid compartments. Blue: DAPI-stained nuclei. Merge-1: DOX-Lysotracker. Merge-2: BF-DOX-Lysotracker-DAPI. Bar =10 μm.

Fig. 4. (A-H) pH-stimulated release of DOX in MCF-7 cells at different time points. Cells were pretreated without (A, B, E, F) and with (C, D, G, H) bafilomycin A1 before addition of DOX-UsMSND@MSN with UsMSND@MSN concentration at 50 μg/mL. Bar = 20 μm. (I) Cytotoxicity results evaluated via the CCK-8 assay. Data are mean ± SD (n = 5, * P < 0.05, ** P < 0.01, *** P < 0.001).

Fig. 5. In vivo CT images in breast cancer and glioma-bearing mice before (left) and after (right) intratumoral injection of PEGylated UsMSND@MSN. (A-D) Reconstructed CT images of the whole body (A, C) of breast cancer-bearing mouse and the brain (B, D) of glioma-bearing mouse, respectively. (x-z) coronal images, (x-y) horizontal images, (z-y) sagittal images. An enhanced CT contrast before and after treatment were shown in the yellow dashed circles.

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Ultra-small MoS₂ nanodots-incorporated mesoporous silica nanospheres for pH-sensitive drug delivery and CT imaging

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