Preliminary Study on Cytotoxic Effect of Biodegradation of Magnesium on Cancer Cells

J. Mater. Sci. Technol. ›› 2012, Vol. 28 ›› Issue (9): 769-772.

• Biomaterials • Next Articles

Preliminary Study on Cytotoxic Effect of Biodegradation of Magnesium on Cancer Cells

Yu Zhang¹⁾, Ling Ren²⁾, Mei Li¹⁾, Xiao Lin²⁾, Huafu Zhao¹⁾, Ke Yang²⁾

1) Department of Orthopedic Surgery, Guangzhou General Hospital of Guangzhou Military Command, Guangzhou 510010, China
2) Institute of Metal Research, Chinese Academy of Sciences, Shenyang 110016, China

Received:2012-07-16 Revised:2012-08-22 Online:2012-09-28 Published:2012-10-31
Supported by:
the National Basic Research Program of China (No. 2012CB619101) and a military medicine research fund (No. CWS11C268)

Abstract

Abstract:

Biodegradation of magnesium (Mg) based metals in body fluid can lead to a strong alkalinity as well as an increase of Mg²⁺ concentration in its surrounding environment. In vitro cytotoxic effects of the extracts of pure Mg with and without micro arc oxidation (MAO) coating on osteosarcoma U2-OS cells, a kind of bone cancer cells, were preliminarily studied, independently considering the increase of either alkalinity or Mg²⁺ concentration. The results indicated that the high alkalinity, i.e., a great increase of pH value, caused by the degradations of Mg with and without MAO coating in the culture medium all showed strong cytotoxic effects on U2-OS cells. However, the increase of Mg²⁺ concentration had no such cytotoxic effect. This finding may provide an alternative way to cure bone cancers through creating a high alkalinity surrounding the cancer cells.

Key words: Magnesium, Biodegradation, Alkalinity, Cancer cell

Yu Zhang, Ling Ren, Mei Li, Xiao Lin, Huafu Zhao, Ke Yang. Preliminary Study on Cytotoxic Effect of Biodegradation of Magnesium on Cancer Cells[J]. J. Mater. Sci. Technol., 2012, 28(9): 769-772.

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Preliminary Study on Cytotoxic Effect of Biodegradation of Magnesium on Cancer Cells

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