Supramolecular G-quadruplex hydrogels: Bridging fabrication to biomedical application

doi:10.1016/j.jmst.2023.01.034

J. Mater. Sci. Technol. ›› 2023, Vol. 155: 238-252.DOI: 10.1016/j.jmst.2023.01.034

Supramolecular G-quadruplex hydrogels: Bridging fabrication to biomedical application

Yuanfeng Li^a,b, Junjie Chi^a,c, Pingwei Xu^a, Xing Dong^a, Anh-Tuan Le^d, Keqing Shi^a,**, Yong Liu^c,*, Jian Xiao^a,b,**

^aTranslational Medicine Laboratory, The Center of Wound Healing and Regenerative Medicine, the First Affiliated Hospital of Wenzhou Medical University, Zhejiang 325035, China;
^bSchool of Pharmaceutical Sciences, Key Laboratory of Biotechnology and Pharmaceutical Engineering, The Center of Wound Healing and Regenerative Medicine, the First Affiliated Hospital, Wenzhou Medical University, Zhejiang 325035, China;
^cWenzhou Institute, University of Chinese Academy of Sciences, Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision and Brain Health), Engineering Research Center of Clinical Functional Materials and Diagnosis & Treatment Devices of Zhejiang Province, Zhejiang 325001, China;
^dPhenikaa University Nano Institute (PHENA), Phenikaa University, Hanoi 12116, Viet Nam

Received:2022-05-20 Revised:2023-01-09 Accepted:2021-01-18 Published:2023-08-20 Online:2023-03-22
Contact: **Translational Medicine Laboratory, The Center of Wound Healing and Regenerative Medicine, the First Affiliated Hospital of Wenzhou Medical University, Zhejiang 325035, China. *E-mail addresses: skochilly@wmu.edu.cn (K. Shi), y.liu@ucas.ac.cn (Y. Liu), xfxj2000@126.com (J. Xiao).

Abstract

Abstract: G-quadruplex hydrogel is a class of self-assembled supramolecular hydrogel formed by guanine derivatives. As a biomimetic hydrogel, G-quadruplex hydrogels demonstrate wide biomedical applications, such as drug delivery, tissue engineering, and biosensing. The advantages of using G-quadruplex hydrogels include adequate biocompatibility and biodegradability, tunable multifunctionality, and cost-effective and large-scalable fabrication process. In this review, we focus on recent progress in the fabrication and characterization of G-quadruplex hydrogels to help readers understand the principles of G-quadruplex hydrogel formation. Meanwhile, the applications of G-quadruplex hydrogels in the biomedical area are discussed, aiming to pave the way for downward clinical or industry translation. The development of G-quadruplex hydrogel is still in its infancy. We hope this review will boost the development of this area and that more applications of G-quadruplex hydrogel will be developed.

Key words: Guanosine, DNA hydrogel, Self-assembly, Drug delivery, Tissue engineering

Yuanfeng Li, Junjie Chi, Pingwei Xu, Xing Dong, Anh-Tuan Le, Keqing Shi, Yong Liu, Jian Xiao. Supramolecular G-quadruplex hydrogels: Bridging fabrication to biomedical application[J]. J. Mater. Sci. Technol., 2023, 155: 238-252.

References

[1] V.S. Chambers, G. Marsico, J.M. Boutell, M. Di Antonio, G.P. Smith, Nat. Biotech- nol. 33(2015) 877-881.
[2] G.W. Collie, G.N. Parkinson, Chem. Soc. Rev. 40(2011) 5867-5892.
[3] I. Bang, Biochem. Z. 26(1910) 293-311.
[4] M. Chen, W.M. Lin, L. Hong, N. Ji, H. Zhao, Biomed. Res. Int. 2019 (2019) 6258248.
[5] J.T. Davis, Angew. Chem. Int. Edit. 43(2004) 668-698.
[6] T. Bhattacharyya, P. Saha, J. Dash, ACS Omega 3 (2018) 2230-2241.
[7] W. Guschlbauer, J.F. Chantot, D. Thiele, J. Biomol. Struct.Dyn. 8(1990) 491-511.
[8] J.T. Davis, G.P. Spada, Chem. Soc. Rev. 36(2007) 296-313.
[9] G.M. Peters, J.T. Davis, Chem. Soc. Rev. 45(2016) 3188-3206.
[10] M. Gellert, M.N. Lipsett, D.R. Davies, Proc. Natl. Acad. Sci. 48(1962) 2013-2018.
[11] L.E. Buerkle, Z. Li, A.M. Jamieson, S.J. Rowan, Langmuir 25 (2009) 8833-8840.
[12] Z. Li, L.E. Buerkle, M.R. Orseno, K.A. Streletzky, S. Seifert, A.M. Jamieson, S.J. Rowan, Langmuir 26 (2010) 10093-10101.
[13] B. Adhikari, A. Shah, H.B. Kraatz, J. Mater. Chem. B 2 (2014) 4802-4810.
[14] R.N. Das, Y.P. Kumar, S. Pagoti, A.J. Patil, J. Dash Chem.Eur. J. 18(2012) 6008-6014.
[15] N. Sreenivasachary, J.M. Lehn, Proc. Natl. Acad. Sci. 102(2005) 5938-5943.
[16] J. Zhang, X.Y. Li, X.P. Sun, A.X. Song, Y.B. Tan, J.C. Hao, Sci. China Chem. 61(2018) 604-612.
[17] Q.M. Ma, M. Zhang, X.H. Xu, K. Meng, C. Yao, Y.F. Zhao, J. Sun, Y.P. Du, D.Y. Yang, ACS Appl. Mater. Interfaces 11 (2019) 47404-47412.
[18] J.J. Hu, H. Wang, Q.Y. Hu, Y.Y. Cheng, Mater. Chem. Front. 3(2019) 1323-1327.
[19] C.G. Wu, X. Wang, Y.F. Shi, B.C. Wang, W. Xue, Y. Zhang, Biomater. Sci. 8(2020) 6190-6203.
[20] H. Zhao, A.H. Schäfer, F. Seela, ChemPlusChem 82 (2017) 826-833.
[21] F. Tang, H. Feng, Y.Q. Du, Y.D. Xiao, H.X. Dan, H. Zhao, Q.M. Chen, Chem. Asian J. 13(2018) 1962-1971.
[22] J.P.M.António, R. Russo, C.P. Carvalho, P.M.S.D. Cal, P.M.P. Gois, Chem. Soc. Rev. 48(2019) 3513-3536.
[23] H.W. Qiao, J.K. Bai, S.C. Zhang, C. Li, RSC Adv. 10(2020) 28536-28540.
[24] A. Biswas, S. Maiti, D.M. Kalaskar, A.K. Das, Chem. Asian J. 13(2018) 3928-3934.
[25] J.J. Li, H.L. Wei, Y. Peng, L.F. Geng, L.M. Zhu, X.Y. Cao, C.S. Liu, H. Pang, Chem. Commun. 55(2019) 7922-7925.
[26] T. Bhattacharyya, Y.P. Kumar, J. Dash, ACS Biomater. Sci. Eng. 3(2017) 2358-2365.
[27] H. Wang, X.Q. Xie, Y. Peng, J.J. Li, C.S. Liu, J. Colloid Interface Sci. 590(2021) 103-113.
[28] X. Li, A. Sánchez-Ferrer, M. Bagnani, J. Adamcik, P. Azzari, J. Hao, A. Song, H. Liu, R. Mezzenga, Proc. Natl. Acad. Sci. U. S. A. 117(2020) 9832-9839.
[29] G.M. Peters, L.P. Skala, T.N. Plank, B.J. Hyman, G.N.Manjunatha Reddy, A.Marsh, S.P. Brown, J.T. Davis, J. Am. Chem. Soc. 136(2014) 12596-12599.
[30] G.M. Peters, L.P. Skala, T.N. Plank, H. Oh, G.N.Manjunatha Reddy, A.Marsh, S.P. Brown, S.R. Raghavan, J.T. Davis, J. Am. Chem. Soc. 137(2015) 5819-5827.
[31] V. Venkatesh, N.K. Mishra, I. Romero-canelo, R.R. Vernooij, H.Y. Shi, J.P.C. Coverdale, A. Habtemariam, S. Verma, P.J. Sadler, Am. Chem. Soc. 139(2017) 5656-5659.
[32] Y.F. Li, Y. Liu, R.J. Ma, Y.L. Xu, Y.L. Zhang, B.X. Li, Y.L. An, L.Q. Shi, ACS Appl. Mater. Interfaces 9 (2017) 13056-13067.
[33] S. Chatterjee, E.V. Anslyn, A. Bandyopadhyay, Chem. Sci. 12(2021) 1585-1599.
[34] A. Biswas, T. Ghosh, P.K. Gavel, A.K. Das, ACS Appl. Bio Mater. 3(2020) 1052-1060.
[35] J.J. Hu, Q.Y. Hu, X. He, C.X. Liu, Y.L. Kong, Y.Y. Cheng, Y.D. Zhang, Adv. Healthc. Mater. 9(2020) 1-8.
[36] Z.Y. Li, G. Davidson-Rozenfeld, M. Vázquez-González, M. Fadeev, J.J. Zhang, H. Tian, I. Willner, J. Am. Chem.Soc. 140(2018) 17691-17701.
[37] E. Hasuike, A.M. Akimoto, R. Kuroda, K. Matsukawa, Y. Hiruta, H. Kanazawa, R. Yoshida, Chem. Commun. 53(2017) 3142-3144.
[38] X.X. Mao, D.S. Mao, T.S. Chen, M. Jalalah, M.S. Al-Assiri, F.A. Harraz, X.L. Zhu, G. X. Li, ACS Appl. Mater. Interfaces 12 (2020) 36851-36859.
[39] C. Wang, M. Fadeev, J.J. Zhang, M. Vázquez-González, G. Davidson-Rozenfeld, H. Tian, I. Willner, Chem. Sci. 9(2018) 7145-7152.
[40] Y.F. Wu, D.Y. Wang, I. Willner, Y. Tian, L. Jiang, Angew. Chem. Int. Edit. 56(2018) 7790-7794.
[41] S. Tanaka, K. Wakabayashi, K. Fukushima, S. Yukami, R. Maezawa, Y. Takeda, K. Tatsumi, Y. Ohya, A. Kuzuya, Chem. Asian J. 12(2017) 2388-2392.
[42] S. Tanaka, S. Yukami, Y. Hachiro, Y. Ohya, A. Kuzuya, Polymers 11 (2019) 1607 Basel.
[43] G. Gottarelli, S. Masiero, G.P. Spada, J. Chem. Soc.Chem. Commun. 24(1995) 2555.
[44] M. Martín-Hidalgo, J.M. Rivera, Chem. Commun. 47(2011) 12485.
[45] S. Lena, P. Neviani, S. Masiero, S. Pieraccini, G.P. Spada, Angew. Chem. Int. Edit. 49(2010) 3657-3660.
[46] D. González-Rodríguez, J.L.J. van Dongen, M.Lutz, A.L. Spek, A.P.H.J. Schenning, E.W. Meijer, Nat. Chem. 1(2009) 151-155.
[47] I. Yoshikawa, J. Li, Y. Sakata, K. Araki, Angew. Chem. Int. Edit. 43(2004) 100-103.
[48] K. Araki, R. Takasawa, I. Yoshikawa, Chem. Commun. 2(2001) 1826-1827.
[49] I. Yoshikawa, S. Yanagi, Y. Yamaji, K. Araki, Tetrahedron 63 (2007) 7474-7481.
[50] L. Simeone, D. Milano, L. De Napoli, C. Irace, A. Di Pascale, M. Boccalon, P. Tecilla, D. Montesarchio, Chem. Eur. J. 17(2011) 13854-13865.
[51] C.N. Gu, Y. Peng, J.J. Li, H. Wang, X.Q. Xie, X.Y. Cao, C.S. Liu, Angew. Chem. Int. Edit. 59(2020) 18768-18773.
[52] P. Qi, X.Y. Li, Z.H. Huang, Y.H. Liu, A.X. Song, J.C. Hao, Colloid Surf. A Physic- ochem.Eng. Asp. 629(2021) 127411.
[53] A. Nuthanakanti, S.G. Srivatsan, ACS Appl. Mater. Interfaces 9 (2017) 22864-22874.
[54] A. Biswas, S. Malferrari, D.M. Kalaskar, A.K. Das, Chem. Commun. 54(2018) 1778-1781.
[55] R.B. Zhong, M.S. Xiao, C.F. Zhu, X.Z. Shen, Q. Tang, W.J. Zhang, L.H. Wang, S.P. Song, X.M. Qu, H. Pei, C. Wang, L. Li, ACS Appl. Mater. Interfaces 10 (2018) 4512-4518.
[56] T. Bhattacharyya, D. Panda, J. Dash, Org. Lett. 23(2021) 3004-3009.
[57] R.B. Zhong, Q. Tang, S.P. Wang, H.B. Zhang, F. Zhang, M.S. Xiao, T.T. Man, X. M. Qu, L. Li, W.J. Zhang, H. Pei, Adv. Mater. 30(2018) 1706887.

Supramolecular G-quadruplex hydrogels: Bridging fabrication to biomedical application

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