Composite demineralized bone matrix nanofiber scaffolds with hierarchical interconnected networks via eruptive inorganic catalytic decomposition for osteoporotic bone regeneration

doi:10.1016/j.jmst.2024.02.018

J. Mater. Sci. Technol. ›› 2024, Vol. 199: 246-259.DOI: 10.1016/j.jmst.2024.02.018

Composite demineralized bone matrix nanofiber scaffolds with hierarchical interconnected networks via eruptive inorganic catalytic decomposition for osteoporotic bone regeneration

Sung Won Ko^a,b,1, Joshua Lee^a,b,1, Ji Yeon Lee^c, Jeong Hwi Cho^d, Sunny Lee^a, Hak Su Jang^e, Chan Hee Park^a,b,f,*, Hyun Jin Tae^d, Cheol Sang Kim^a,b,f,*, Young Min Oh^g,*

^aDepartment of Bionanosystem Engineering, Jeonbuk National University, Jeonju, Republic of Korea;
^bDepartment of Bionanotechnology and Bioconvergence Engineering, Graduate School, Jeonbuk National University, Jeonju, Republic of Korea;
^cDepartment of Mechanical Design Engineering, Graduate School, Jeonbuk National University, Jeonju, Republic of Korea;
^dCollege of Veterinary Medicine and Bio-safety Research Institute, Jeonbuk National University, Iksan, Republic of Korea;
^eR& D Center, CGBIO Inc, Seongnam, Republic of Korea;
^fDivision of Mechanical Design Engineering, Jeonbuk National University, Jeonju, Republic of Korea;
^gDepartment of Neurosurgery, Research Institute of Clinical Medicine, Jeonbuk National University Medical, School and Hospital, Jeonju, Republic of Korea

Received:2023-03-06 Revised:2024-01-23 Accepted:2024-02-05 Published:2024-11-10 Online:2024-11-07
Contact: ^*E-mail addresses: biochan@jbnu.ac.kr (C.H. Park), chskim@jbnu.ac.kr (C.S. Kim), timoh@jbnu.ac.kr (Y.M. Oh)
About author:¹The authors contributed equally to this work.

Abstract

Abstract: Demineralized bone matrix (DBM) is one of the standard biomaterials used to fill surgical bone defects in general orthopedic procedures. However, current DBM products come in the form of powder or viscous solutions that fail to mimic the natural hierarchical structure of bone while also using large amounts of valuable material. To overcome this, compact fibrous DBM/polymer (fDBM) composites were prepared via electrospinning. Then, by exploiting the catalytic decomposition of hydrogen peroxide, oxygen pockets are formed in the scaffold imparting it with a hierarchical porous structure similar to bone (Op-fDBM). These pockets created by bubbles of oxygen help give the scaffold a mechanically stable shape while the incorporated DBM supports cell adhesion and growth. In vivo evaluations reveal that fDBM increased bone volume by 41.7 % while Op-fDBM increased bone volume by 68.6 %. Significant increases in regenerated bone volume with the use of minimal amounts of DBM in fiber form go to show the great potential of this work in the field of bone regeneration.

Key words: Demineralized bone matrix, Hierarchical networks, Catalytic decomposition, Bone regeneration

Sung Won Ko, Joshua Lee, Ji Yeon Lee, Jeong Hwi Cho, Sunny Lee, Hak Su Jang, Chan Hee Park, Hyun Jin Tae, Cheol Sang Kim, Young Min Oh. Composite demineralized bone matrix nanofiber scaffolds with hierarchical interconnected networks via eruptive inorganic catalytic decomposition for osteoporotic bone regeneration[J]. J. Mater. Sci. Technol., 2024, 199: 246-259.

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Composite demineralized bone matrix nanofiber scaffolds with hierarchical interconnected networks via eruptive inorganic catalytic decomposition for osteoporotic bone regeneration

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