Abstract: Magnesium phosphate cements have come under investigation in recent years for use as an alternative to calcium phosphate cements for bone void repair applications. Evidence indicates that magnesium phosphate cements obtain higher initial strengths after cement reaction and resorption in more clinically appropriate time frames than commercially available calcium phosphate cements. In this study, amorphous, partially amorphous and crystalline tri-magnesium phosphate powders were synthesized via an aqueous precipitation reaction with subsequent thermal treatment, and characterized using techniques such as X-ray diffraction and Fourier transform infrared spectroscopy. These materials were assessed for their functionality in cementing reaction with a 3.0 mol/L, pH 7.0 ammonium phosphate solution, including setting time and pH evolution in phosphate buffered saline solution. Results indicated that the amorphous and semi-crystalline tri-magnesium phosphate powders were highly reactive with the setting solution but resulted in mechanically weak cements, while the crystalline tri-magnesium phosphate powder reacted efficiently with the cement solution and were mechanically strong following the cement reaction. X-ray diffraction and scanning electron microscopy analyses indicated significant changes in the phase composition and morphology of the cements following incubation in phosphate buffered saline. These were perceived to be detrimental to the integrity of the amorphous and semi-crystalline tri-magnesium phosphate derived cements but not to those created with fully crystalline tri-magnesium phosphate. The crystalline tri-magnesium phosphate material resulted in the most functional cement as this embodiment displayed the most clinically relevant setting time as well as the highest mechanical resilience and neutral pH during incubation in saline solution rendering them potentially viable as bone void fillers.

Key words: Amorphous magnesium phosphate, Tri-magnesium phosphate, Bone cement, Bone regeneration, Struvite