Nickel phosphide for MRI-guided synergistic photo-immunotherapy

doi:10.1016/j.jmst.2022.12.032

Abstract

Abstract: Developing a phototherapy modality to ablate tumor and then trigger immunogenic cell death (ICD) for simultaneously eliminating distal and metastatic tumors holds great promise in clinical applications. Herein, the polyethylene glycol functionalized Ni₂P (Ni₂P@PEG NPs) is developed with enhanced biocompatibility, high photoabsorption and photothermal efficiency, as well as reactive oxygen species generation ability. Of particular note, Ni₂P@PEG NPs mediated phototherapy could not only realize efficient ablation of primary tumors, but also inhibit distal tumors and metastatic tumors by triggering an antitumor immune response. The above conclusions were verified by B mode ultrasound, western blot assay, and immunohistochemistry analysis. Meanwhile, Ni₂P@PEG NPs showed excellent magnetic resonance imaging (MRI) properties. In summary, the MRI-guided multimodal cancer therapies of Ni₂P@PEG NPs represent significant potential for clinical applications.

Key words: Nickel phosphide, Magnetic resonance imaging, Phototherapy, Immunotherapy

Na An, Yan Gao, Ying Shi, Xingxing Du, Jianing Cheng, Shuanglong Tang, Pengfei Liu, Huike Yang, Chongshen Guo. Nickel phosphide for MRI-guided synergistic photo-immunotherapy[J]. J. Mater. Sci. Technol., 2023, 151: 150-161.

References

[1] M.Y. Chang, Z.Y. Hou, M. Wang, C.X. Li, J. Lin, Adv. Mater. 33(2020) 2004788.
[2] J. Yu, Q.X. Mu, M. Fung, X.L. Xu, L.X. Zhu, R.J.Y.Ho, Pharmacol. Ther. 236(2022) 108108.
[3] T.T. Wang, D.G. Wang, H.J. Yu, B. Feng, F.Y. Zhou, H.W. Zhang, L. Zhou, S. Jiao, Y.P. Li, Nat. Commun. 9(2018) 1532.
[4] L. Zhou, Y.W. Xi, Y.M. Xue, M. Wang, Y.L. Liu, Y. Gao, B. Lei, M.Z. Yin, Adv. Funct. Mater. 31(2021) 2170319.
[5] C.D. Ji, W.Y. Cheng, Y.S. Hu, Y.F. Liu, F.Y. Liu, Nano Today 36 (2021) 101020.
[6] M. Gao, J. Deng, F. Liu, A.P. Fan, Y.J. Wang, H.Y. Wu, D. Ding, D.L. Kong, Z. Wang, D. Peer, Y.J. Zhao, Biomaterials 223 (2019) 119486.
[7] W.P. Fan, B. Yung, P. Huang, X.Y. Chen, Chem. Rev. 117(2017) 13566-13638.
[8] D. Jana, Y.L. Zhao, Exploration 2 (2022) 20210238.
[9] B.Q. Guo, J.L. Zhao, Z.L. Zhang, X. An, M.X. Huang, S.G. Wang, Chem. Eng. J. 391(2019) 123609.
[10] J. Wahsner, E.M. Gale, A. Rodriguez-Rodriguez, P. Caravan, Chem. Rev. 119(2019) 957-1057.
[11] Z.W. Zhou, Y.D. Liu, M.H. Zhang, C.Z. Li, R.X. Yang, J. Li, C.G. Qian, M.J. Sun, Adv. Funct. Mater. 29(2019) 1904144.
[12] P. Stratta, C. Canavese, S. Aime, Curr. Med. Chem. 15(2008) 1229-1235.
[13] H. Ersoy, F.J. Rybicki, J. Magn. Reson. Imaging 26 (2007) 1190-1197.
[14] J. Chen, T.X. Chen, Q.L. Fang, C.S. Pan, O.U. Akakuru, W.Z. Ren, J. Lin, A.Z. Sheng, X. H. Ma, A.G.Wu, Exploration(2022) 20220014.
[15] Y.Z.W. Weng, S.Y. Guan, L. Wang, H. Lu, X.M. Meng, G.I.N. Waterhouse, S.Y. Zhou, Small 16 (2019) 1905184.
[16] B.S. Ouyang, F.N. Liu, S.R. Ruan, Y. Liu, H.S. Guo, Z.X. Cai, X.R. Yu, Z.Q. Pang, S. Shen, ACS Appl. Mater. Interfaces 11 (2019) 38555-38567.
[17] B. Guo, Z.M. Huang, Q. Shi, E. Middha, S.D. Xu, L. Li, M. Wu, J.W. Jiang, Q.L. Hu, Z.W. Fu, B. Liu, Adv. Funct. Mater. 30(2019) 1907093.
[18] E. Haimov-Talmoud, Y. Harel, H. Schori, M. Motiei, A. Atkins, R. Popovtzer, J.P. Lellouche, O. Sheﬁ, ACS Appl. Mater. Interfaces 11 (2019) 45368-45380.
[19] Z.Y. Liu, T.Y. Cao, Y.D. Xue, M.T. Li, M.S. Wu, J.W. Engle, Q.J. He, W.B. Cai, M. B. Lan, W.A. Zhang, Angew. Chem. Int. Ed. 59(2020) 3711-3717.
[20] C. Chen, X. Ni, S.R. Jia, Y. Liang, X.L. Wu, D.L. Kong, D. Ding, Adv. Mater. 31(2019) 1904914.
[21] W. Li, J. Yang, L.H. Luo, M.S. Jiang, B. Qin, H. Yin, C.Q. Zhu, X.L. Yuan, J.L. Zhang, Z.Y. Luo, Y.Z. Du, Q.P. Li, Y. Lou, Y.Q. Qiu, J. You, Nat. Commun. 10(2019) 3349.
[22] Y. Zhao, Z.Z. Zhang, Z. Pan, Y. Liu, Exploration 1 (2021) 20210089.
[23] H. Wang, D.D. Su, R.F. Huang, F. Shu, F. Cheng, G. Zheng, Acta Biomater. 134(2021) 674-685.
[24] T. Yano, K. Hatogai, H. Morimoto, Y. Yoda, K. Kaneko, Ann. Transl. Med. 2(2014) 29.
[25] J. Dai, M. Wu, Q. Wang, S.Y. Ding, X.Q. Dong, L.R. Xue, Q.Q. Zhu, J. Zhou, F. Xia, S. X. Wang, Y. Hong, Natl. Sci. Rev. 8 (2021) nwab039.
[26] X.K. Zhang, S.B. Yang, Q. Wang, W.M. Ye, S.L. Liu, X. Wang, Z.Y. Zhang, L.Y. Cao, X. Q. Jiang, Chem. Eng. J. 423(2021) 130083.
[27] H.R. Wang, X. Han, Z.L. Dong, J. Xu, J. Wang, Z. Liu, Adv. Funct. Mater. 29(2019) 1902440.
[28] Y.F. Zhang, Y.Y. Liao, Q.N. Tang, J. Lin, P. Huang, Angew. Chem. Int. Ed. 60(2021) 10647-10653.
[29] H. Zhu, J.L. Fan, B.H. Wang, X.J. Peng, Chem. Soc. Rev. 44(2015) 4337-4366.
[30] D.M. Sang, K. Wang, X.L. Sun, Y. Wang, H.M. Lin, R. Jia, F.Y. Qu, ACS Appl. Mater. Interfaces 13 (2021) 9604-9619.
[31] W.X. Hu, W.Y. Zhen, M.C. Zhang, W. Wang, X.D. Jia, S.J. An, Y. Wang, Z. Guo, X. E. Jiang, Adv. Healthcare Mater. 10(2021) 2101542.
[32] G. He, Y. Ma, H. Zhou, S.Y. Sun, X.W. Wang, H.S. Qian, Y. Xu, Z.H. Miao, Z. Zha, J. Mater. Chem. B 7 (2019) 143-149.
[33] D.Y. Gao, P.F. Zhang, C.B. Liu, C. Chen, G.H. Gao, Y.Y. Wu, Z.H. Sheng, L. Song, L. T. Cai, Nanoscale 7 (2015) 17631-17636.
[34] Y. Liu, W.Y. Zhen, Y.H. Wang, J.H. Liu, L.H. Jin, T.Q. Zhang, S.T. Zhang, Y. Zhao, N. Yin, R. Niu, S.Y. Song, L. Zhang, H. Zhang, Nano Lett. 19(2019) 5093-5101.
[35] Y. Lu, P. Zhang, L.H. Lin, X. Gao, Y.F. Zhou, J. Feng, H.J. Zhang, Dalton Trans. 51(2022) 4 423-4 428.
[36] H. Zhou, X.D. Zeng, A.G. Li, W.Y. Zhou, L. Tang, W.B. Hu, Q.L. Fan, X.L. Meng, H. Deng, L. Duan, Y.Q. Li, Z.X. Deng, X.C. Hong, Y.L. Xiao, Nat. Commun. 11(2020) 6183.
[37] L.H. Lu, W.H. Chen, Z. Sun, C.H. Jiang, W.B. Sun, B. Yu, W. Wang, Angew. Chem. Int. Ed. 60(2021) 16641-16648.
[38] T.C. Chou, Pharmacol. Rev. 58(2006) 621-681.
[39] T.C. Chou, Synergy 7 (2018) 49-50.
[40] L.L. Bu, L. Rao, G.T. Yu, L. Chen, W.W. Deng, J.F. Liu, H. Wu, Q.F. Meng, S.S. Guo, X. Z. Zhao, W.F. Zhang, G. Chen, Z. Gu, W. Liu, Z.J. Sun, Adv. Funct. Mater. 29(2019) 201807733.
[41] Z.M. Tang, Y.Y. Liu, D.L. Ni, J.J. Zhou, M. Zhang, P.R. Zhao, B. Lv, H. Wang, D. Y. Jin, W.B. Bu, Adv. Mater. 32(2020) 1904011.
[42] C.Y. Yang, Y.D. Chen, W. Guo, Y. Gao, C.Q. Song, Q. Zhang, N.N. Zheng, X.J. Han, C. S. Guo, Adv. Funct. Mater. 28(2018) 201706827.
[43] W. Zhang, C.C. Zhang, X.Y. Wang, L. Li, Q.Q. Chen, W.W. Liu, Y. Cao, H.T. Ran, ACS Appl. Mater. Interfaces 12 (2020) 4 8420-4 8431.
[44] E.B. Ehlerding, F. Chen, W.B. Cai, Adv. Sci. 3(2016) 1500223.
[45] X.P. Duan, Y.P. Li, Small 9 (2013) 1521-1532.
[46] L. Brannon-Peppas, J.O. Blanchette, Adv. Drug Deliv. Rev. 64(2012) 206-212.
[47] L. Zhou, P.P. Zhang, H. Wang, D.G. Wang, Y.P. Li, Acc. Chem. Res. 53(2020) 1761-1772.
[48] F.F. Zhou, D. Xing, W.R. Chen, Int. J. Cancer 125 (2009) 1380-1389.
[49] M.L. Chen, D. Yang, Y. Sun, T. Liu, W.H. Wang, J.T. Fu, Q.Q. Wang, X.Q. Bai, G. L. Quan, X. Pan, C.B. Wu, ACS Nano 15 (2021) 3387-3401.
[50] W.W. Yue, L. Chen, L.D. Yu, B.G. Zhou, H.H. Yin, W.W. Ren, C. Liu, L.H. Guo, Y.F. Zhang, L.L. Sun, K. Zhang, H.X. Xu, Y. Chen, Nat. Commun. 10(2019) 2025.
[51] J. Wang, Y.Z. Chang, H. Luo, W.X. Jiang, L.G. Xu, T.F. Chen, X. Zhu, Biomaterials 255 (2020) 120153.
[52] Y.Y. Cheng, Q. Chen, Z.Y. Guo, M.W. Li, X.Y. Yang, G.Y. Wan, H.L. Chen, Q.Q. Zhang, Y.S. Wang, ACS Nano 14 (2020) 15161-15181.