Bioactive calcium and mangnesium phosphate bone adhesive for enhanced vascularization and bone regeneration

doi:10.1016/j.jmst.2023.04.057

J. Mater. Sci. Technol. ›› 2023, Vol. 164: 246-257.DOI: 10.1016/j.jmst.2023.04.057

• Research Article • Previous Articles

Bioactive calcium and mangnesium phosphate bone adhesive for enhanced vascularization and bone regeneration

Jiawei Liu^a,1, Honglei Kang^b,1, Wenying Wei^a, Rong Tu^a, Takashi Goto^a,d, Feng Li^b,*, Honglian Dai^a,c,**

^aState Key Laboratory of Advanced Technology for Materials Synthesis and Processing, Biomedical Materials and Engineering Research Center of Hubei Province, Wuhan University of Technology, Wuhan 430070, China
^bDepartment of Orthopedics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
^cChaozhou Branch of Chemistry and Chemical Engineering Guangdong Laboratory, Chaozhou 521000, China
^dNew Industry Creation Hatchery Center, Tohoku University, Sendai 980-8579, Japan

Received:2023-01-23 Revised:2023-04-15 Accepted:2023-04-26 Published:2023-11-20 Online:2023-11-15
Contact: ^**State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, Biomedical Materials and Engineering Research Center of Hubei Province, Wuhan University of Technology, Wuhan 430070, China.
^*E-mail addresses: lifengmd@hust.edu.cn (F. Li), daihonglian@whut.edu.cn (H. Dai).
About author:¹These authors contributed equally to this work.

Abstract

Abstract: Bone adhesive is a promising material for the treatment of bone fractures, which is helpful for the fast and effective reduction and fixation of broken bones. However, the existing adhesives bond weakly to bone tissues, and are non-absorbable, or hard to cure under wet conditions. Herein, inspired by the cement-based adhesive used in the industry field, we report a bioactive calcium and magnesium phosphate bone adhesive (MPBA) with the properties of facile preparation, robust adhesion, and bioactive. MPBA is equipped with similar strength to cancellous bones and shows reliable bonding performance for various interfaces, such as Ti₆Al₄V, Al₂O₃, and poly(ether-ether-ketone). MPBA achieves excellent bonding ability for the above interfaces with the bonding strengths of 2.28±0.47, 2.32±0.15, and 1.44±0.38 MPa, respectively. Besides, it also shows reliable fixation ability for bovine bone surfaces. The bonding behavior to materials and bones suggests that MPBA could be used for both fracture treatment and implant fixation. Meanwhile, MPBA possesses good biological activity, which could promote the vascularization process and osteogenic differentiation. Finally, in vivo experiments confirmed MPBA can effectively restore bone strength and promote bone regeneration.

Key words: Fracture, Calcium magnesium phosphate cement, Bone adhesives

Jiawei Liu, Honglei Kang, Wenying Wei, Rong Tu, Takashi Goto, Feng Li, Honglian Dai. Bioactive calcium and mangnesium phosphate bone adhesive for enhanced vascularization and bone regeneration[J]. J. Mater. Sci. Technol., 2023, 164: 246-257.

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Bioactive calcium and mangnesium phosphate bone adhesive for enhanced vascularization and bone regeneration

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