Multifunctional microsphere dressings via metal ligand bonding engineering for infectious wound healing

doi:10.1016/j.jmst.2024.08.036

J. Mater. Sci. Technol. ›› 2025, Vol. 219: 158-172.DOI: 10.1016/j.jmst.2024.08.036

• Research article • Previous Articles Next Articles

Multifunctional microsphere dressings via metal ligand bonding engineering for infectious wound healing

Zhongyi Sun^a,1, Ningning Cheng^b.1, Zhuyun Cai^c, Zhengran Ying^a, Haibo Liu^d, Ziyan Chen^a, Hua Zeng^a, Mengting Yin^a, Haijiang Liu^e, Shuo Tan^a, Xuhui Zhou^*, Xinyu Zhao^a,*, Feng Chen^*

^aCenter for Orthopaedic Science and Translational Medicine, Department of Orthopaedics, School of Medicine, Tongji University, Shanghai Tenth People’s Hospital, Shanghai 200072, China
^bDepartment of Radiation Oncology, Shanghai General Hospital, Shanghai Jiaotong University, Shanghai 201600, China
^cDepartment of Orthopedics, Changzheng Hospital, Second Military Medical University (Naval Medical University), Shanghai 200003, China
^dSuzhou First People’s Hospital, School of Medicine, Anhui University of Science and Technology, Huainan 232001, China
^eShanghai Key Laboratory of Craniomaxillofacial Development and Diseases, Shanghai Stomatological Hospital & School of Stomatology, Fudan University, Shanghai 201102, China
^fTranslational Research Center of Orthopedics, Shanghai General Hospital, Shanghai Jiaotong University, Shanghai 200080, China

Received:2024-06-17 Revised:2024-07-30 Accepted:2024-08-12 Published:2024-09-13 Online:2025-06-05
Contact: *E-mail addresses:cz_zhouxuhui@163.com (X. Zhou),xyzhao@tongji.edu.cn (X. Zhao),chen_feng@fudan.edu.cn (F. Chen)
About author:¹These authors contributed equally to this work.

Abstract

Abstract: Surgical incision infection is the most common postoperative complication that poses a serious threat to human health. In this work, the iron gallate (GA-Fe) modified hyaluronic acid microspheres (GFe@HAMSs) multifunctional dressings with antibacterial activity, biodegradability, and the ability to promote tissue regeneration for infectious wound healing are prepared via the bonding engineering between bioactive iron ions and ligands from both polyphenol (i.e. gallic acid, GA) and HAMSs matrix. In our strategy, the Fe-HAMS interaction is first constructed, leading to the shrinkage of iron-doped HAMSs (Fe@HAMSs). Then, the addition of GA further tunes the metal-matrix bonding by introducing the competitive equilibrium between Fe-HAMS and Fe-GA chelation, leading to the volume expansion of GFe@HAMSs. The introduction of iron ions can effectively shorten the inflammatory response and reverse the iron-deficient microenvironment, thereby transforming the wound microenvironment into one conducive to tissue regeneration. Benefitting from these bioactive effects of iron ions and the photothermal antibacterial activity of GA-Fe, the GFe@HAMSs significantly accelerate the wound healing process for rat skin-infected wounds by inhibiting the inflammatory response and macrophage polarization and promoting angiogenesis and tissue remodeling. The GFe@HAMSs proposed in this work not only provide a biomaterial for infectious wound healing but also offer a new strategy for designing multifunctional dressing.

Key words: Iron gallate, Hydrogel, Microsphere, Photothermal therapy, Tissue regeneration

Zhongyi Sun, Ningning Cheng, Zhuyun Cai, Zhengran Ying, Haibo Liu, Ziyan Chen, Hua Zeng, Mengting Yin, Haijiang Liu, Shuo Tan, Xuhui Zhou, Xinyu Zhao, Feng Chen. Multifunctional microsphere dressings via metal ligand bonding engineering for infectious wound healing[J]. J. Mater. Sci. Technol., 2025, 219: 158-172.

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Multifunctional microsphere dressings via metal ligand bonding engineering for infectious wound healing

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