Regulation of TiO2 nanoarrays on titanium implants for enhanced osteogenic activity and immunomodulation

doi:10.1016/j.jmst.2022.12.023

Abstract

Abstract: The surface topography of implants plays a major role in osteogenesis and immunomodulation. In this study, three types of TiO₂ nanoarrays including nanorod arrays with a diameter of 45 nm (TiO₂-N), nanorod arrays with a diameter of 60 nm (TiO₂-N N), and nanocone arrays (TiO₂-NW) are prepared on titanium and the behavior of bone marrow stromal cells (BMSCs) and polarization of macrophages are studied. Compared to the planar titanium control, TiO₂ nanoarrays facilitate osteogenesis of BMSCs and stimulate the pro-healing M2 phenotype. However, adhesion, spreading, proliferation, and osteogenic differentiation of BMSCs are more pronounced on TiO₂-N N than both TiO₂-N and TiO₂-NW. TiO₂-NN also produces the best immune microenvironment, while TiO₂-NW is more favorable than TiO₂-NN from the viewpoint of cell adhesion and spreading of osteoblasts.

Key words: TiO₂ nanoarrays, Osteogenic activity, Immunomodulation, Hydrothermal treatment

Ruoyu Li, Hongyu Zhang, Xiaohong Yao, Bin Tang, Paul K Chu, Xiangyu Zhang. Regulation of TiO₂ nanoarrays on titanium implants for enhanced osteogenic activity and immunomodulation[J]. J. Mater. Sci. Technol., 2023, 150: 233-244.

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Regulation of TiO₂ nanoarrays on titanium implants for enhanced osteogenic activity and immunomodulation

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