J. Mater. Sci. Technol. ›› 2014, Vol. 30 ›› Issue (10): 979-983.DOI: 10.1016/j.jmst.2014.07.007

• Orginal Article • Previous Articles     Next Articles

In Vitro Comparative Effect of Three Novel Borate Bioglasses on the Behaviors of Osteoblastic MC3T3-E1 Cells

Xiaojuan Wei1, 2, Tingfei Xi1, Yufeng Zheng2, Changqing Zhang3, Wenhai Huan   

  1. 1. Academy for Advanced Interdisplinary Studies, Peking University, Beijing 100871, China;
    2.College of Engineering, Peking University, Beijing 100871, China;
    3.Department of Orthopaedics, Shanghai Sixth People’s Hospital, Shanghai Jiaotong University, Shanghai 200233, China;
    4.Institute of Bio-engineering and Information Technology Materials, School of Materials Science and Engineering,Tongji University, Shanghai 200092, China
  • Received:2013-12-04 Online:2014-10-20 Published:2014-11-04
  • Contact: Prof.; Tel./Fax: t86 10 62753404; E-mailaddress: xitingfei@pku.edu.cn (T. Xi).

Abstract: Most related investigations focused on the effects of borate glass on cell proliferation/biocompatibility in vitro or bone repair in vivo; however, very few researches were carried out on other cell behaviors. Three novel borate bioglasses were designed as scaffolds for bone regeneration in this wok. Comparative effects of three bioglasses on the behaviors of osteoblastic MC3T3-E1 cells were evaluated. Excellent cytocompatibility of these novel borate bioglasses were approved in this work. Meanwhile, the promotion on cell proliferation, protein secretion and migration with minor cell apoptosis were also discussed in details, which contributed to the potential clinical application as a new biomaterial for orthopedics.

Key words: Comparative study, Borate bioglass, Osteoblastic cells, Cell behavior, In vitro