Antibacterial Properties of Ti–6Al–4V– x Cu Alloys

doi:10.1016/j.jmst.2013.12.014

J. Mater. Sci. Technol. ›› 2014, Vol. 30 ›› Issue (7): 699-705.DOI: 10.1016/j.jmst.2013.12.014

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Antibacterial Properties of Ti–6Al–4V– x Cu Alloys

Ren Ling¹, Ma Zheng¹, Li Mei², Zhang Yu², Liu Weiqiang³, Liao Zhenhua³, Yang Ke^{1, *}

1. Institute of Metal Research, Chinese Academy of Sciences, Shenyang 110016, China; 2. Department of Orthopedic Surgery, Guangzhou General Hospital of Guangzhou Military Command, Guangzhou 510010, China; 3. Research Institute of Tsinghua University in Shenzhen, Shenzhen High-Tech Industrial Estate, Shenzhen 518057, China

Received:2013-07-22 Online:2014-07-20 Published:2014-07-30
Contact: Corresponding author. Prof., Ph.D.; Tel.: +86 24 23891320

Abstract

Abstract: Surgical implant-associated bacterial infection is becoming a serious clinical problem. A series of copper-bearing titanium alloy, Ti–6Al–4V– x Cu (x = 1, 3, 5 wt%), were fabricated in the present study in order to reduce the hazard of the bacterial infection problem by means of the strong antibacterial ability of Cu element. The metallography, X-ray diffraction, antibacterial ability, corrosion resistance and cytotoxicity of Ti–6Al–4V– x Cu alloys were preliminarily studied with comparison to the commercial medical Ti–6Al–4V alloy. The Ti–6Al–4V– x Cu alloys showed obvious antibacterial abilities with good corrosion resistance and cytocompatibility, and the antibacterial role was enhanced with increasing Cu content, which has significant potential for clinical applications as surgical implant materials.

Key words: Ti–6Al–4V, Cu-bearing titanium alloy, Antibacterial property

Ren Ling, Ma Zheng, Li Mei, Zhang Yu, Liu Weiqiang, Liao Zhenhua, Yang Ke. Antibacterial Properties of Ti–6Al–4V– x Cu Alloys[J]. J. Mater. Sci. Technol., 2014, 30(7): 699-705.

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Antibacterial Properties of Ti–6Al–4V– x Cu Alloys

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