A versatile 3D-printable hydrogel for antichondrosarcoma, antibacterial, and tissue repair

doi:10.1016/j.jmst.2022.07.010

Abstract

Abstract: Following operative treatment of chondrosarcoma, post-surgery tissue reconstruction may be confronted with daunting challenges, including the delayed self-repair of defective tissue, tumor recurrence, and bacterial infection. To overcome these challenges, a methacrylic anhydride (MA) modified sericin (SerMA) solution mixed with procyanidins (PC) loaded polydopamine (PDA) modified ZIF-8 (PC@ZIF-8@PDA) nanoparticles to form a multifunctional PC@ZIF-8@PDA/SerMA hydrogel after exposure under blue light. Hydrogel products with pre-designed shapes were printed out by using the SerMA solution carrying PC@ZIF-8@PDA nanoparticles and chondrocytes, indicating that PC@ZIF-8@PDA/SerMA hydrogels with personalized shapes can be fabricated via 3D printing. Photocrosslinked PC@ZIF-8@PDA/SerMA hydrogel is able to kill chondrosarcoma cells and bacteria, like Staphylococcus aureus (S. aureus), and Escherichia coli (E. coli), by its photothermal activity combined with near-infrared radiation (NIR). The PC@ZIF-8@PDA/SerMA hydrogel exhibited an antioxidative activity and a good biocompatibility and was easily monitored by its florescent and photoacoustic properties. Rabbit articular cartilage defects were efficiently repaired by PC@ZIF-8@PDA/SerMA hydrogels with encapsulated corresponding autologous chondrocytes, and mice skin burning wounds were swiftly regenerated by applying this hydrogel. Hence, the PC@ZIF-8@PDA/SerMA hydrogel can be potentially applied to the clinic treatment of chondrosarcoma and tissue defect repair after chondrosarcoma resection due to its multifunction in the future.

Key words: Hydrogel, Sericin, ZIF-8, Chondrosarcoma, Cartilage repair

Wenxiang Zhu, Zheng Zhou, Yuting Huang, Hairong Liu, Ning He, Xiaolong Zhu, Xiaoxiao Han, Dengming Zhou, Xuanchu Duan, Xin Chen, Yahui He, Xiaolin Meng, Shuai Zhu. A versatile 3D-printable hydrogel for antichondrosarcoma, antibacterial, and tissue repair[J]. J. Mater. Sci. Technol., 2023, 136: 200-211.

References

[1] N. Shinohara, S. Maeda, Y. Yahiro, D. Sakuma, K. Matsuyama, K. Imamura, I. Kawamura, T. Setoguchi, Y. Ishidou, S. Nagano, S. Komiya, Sci. Rep. 7(2017) 13494.
[2] H.A. Tawbi, M. Burgess, V. Bolejack, B.A.V.Tine, S.M. Schuetze, J. Hu, S.D'Angelo, S. Attia, R.F. Riedel, D.A. Priebat, S. Movva, L.E. Davis, S.H. Okuno, D.R. Reed, J. Crowley, L.H. Butterﬁeld, R. Salazar, J. Rodriguez-Canales, A.J. Lazar, I.I. Wistuba, L.H. Baker, R.G. Maki, D. Reinke, S. Patel, Lancet Oncol. 18(2017) 1565-1566.
[3] M. Li, L. Ren, L.H. Li, P. He, G.B. Lan, Y. Zhang, K. Yang, J. Mater. Sci.Technol. 30(2014) 888-893.
[4] J. Yin, Q. Han, J. Zhang, Y. Liu, X. Gan, K. Xie, L. Xie, Y. Deng, ACS Appl. Mater. Interfaces 12 (2020) 45891-45903.
[5] L. Wang, Q. Yang, M. Huo, D. Lu, Y. Gao, Y. Chen, H. Xu, Adv. Mater. 33(2021) 2100150.
[6] W. Niu, Y. Guo, Y. Xue, M. Wang, M. Chen, D.D. Winston, W. Cheng, B. Lei, Nano Today 38 (2021) 101137.
[7] J.-Y. Sun, X. Zhao, W.R.K. Illeperuma, O. Chaudhuri, K.H. Oh, D.J. Mooney, J.J. Vlassak, Z. Suo, Nature 489 (2012) 133-136.
[8] Y.S. Zhang, A. Khademhosseini, Science 356 (2017) eaaf3627.
[9] J. Maihöfer, H. Madry, A. Rey-Rico, J.K. Venkatesan, L. Goebel, G. Schmitt, S. Speicher-Mentges, X. Cai, W. Meng, D. Zurakowski, M.D. Menger, M.W. Laschke, M. Cucchiarini, Adv. Mater. 33(2021) 2008451.
[10] Y.-Y. Jo, H.Kweon, J.-H. Oh, Appl. Sci. 10(2020) 8457.
[11] C. Qi, L. Xu, Y. Deng, G. Wang, Z. Wang, L. Wang, Biomater. Sci. 6(2018) 2859-2870.
[12] C. Qi, J. Liu, Y. Jin, L. Xu, G. Wang, Z. Wang, L. Wang, Biomaterials 163 (2018) 89-104.
[13] S. Sapru, S. Das, M. Mandal, A.K. Ghosh, S.C. Kundu, Int. J. Biol. Macromol. 137(2019) 545-553.
[14] G. Zhang, Z. Wu, Y. Yang, J. Shi, J. Lv, Y. Fang, Z. Shen, Z. Lv, P. Li, X. Yao, W. Chen, X. Wei, P.K. Chu, X. Zhang, Chem. Eng. J. 428(2022) 131155.
[15] J. Chen, X. Li, X. Zhao, Q. Wu, H. Zhu, Z. Mao, C. Gao, Bioactive Mater. 3(2018) 347-354.
[16] W. Zhu, M. Chen, Y. Liu, Y. Tian, Z. Song, G. Song, X. Zhang, Nanoscale 11 (2019) 20630-20637.
[17] L. Ma, X. Feng, H. Liang, K. Wang, Y. Song, L. Tan, B. Wang, R. Luo, Z. Liao, G. Li, X. Liu, S. Wu, C. Yang, Mater. Today 36 (2020) 48-62.
[18] F. Rossella, C. Soldano, V. Bellani, M. Tommasini, Adv. Mater. 24(2012) 2453-2458.
[19] T. Yin, J. Liu, Z. Zhao, Y. Zhao, L. Dong, M. Yang, J. Zhou, M. Huo, Adv. Funct. Mater. 27(2017) 1604620.
[20] T. Liu, S. Shi, C. Liang, S. Shen, L. Cheng, C. Wang, X. Song, S. Goel, T.E. Barnhart, W. Cai, Z. Liu, ACS Nano 9 (2015) 950-960.
[21] X. Wang, T. Li, H. Ma, D. Zhai, C. Jiang, J. Chang, J. Wang, C. Wu, NPG Asia Mater. 9(2017) e376.
[22] W. Hu, T. Xiao, D. Li, Y. Fan, L. Xing, X. Wang, Y. Li, X. Shi, M. Shen, Adv. Sci. 8(2021) 2100165.
[23] S. Gan, X. Tong, Y. Zhang, J. Wu, Y. Hu, A. Yuan, Adv. Funct. Mater. 29(2019) 1902757.
[24] H.G. Derami, P. Gupta, K.-C. Weng, A.Seth, R. Gupta, J.R. Silva, B. Raman, S. Singamaneni, Adv. Mater. 33(2021) 2008809.
[25] H. Zhao, Y. Chao, J. Liu, J. Huang, J. Pan, W. Guo, J. Wu, M. Sheng, K. Yang, J. Wang, Z. Liu, Theranostics 6 (2016) 1833-1843.
[26] Y. Li, C. Jiang, D. Zhang, Y. Wang, X. Ren, K. Ai, X. Chen, L. Lu, Acta Biomater. 47(2017) 124-134.
[27] B. Li, T. Gong, N. Xu, F. Cui, B. Yuan, Q. Yuan, H. Sun, L. Wang, J. Liu, Small 16 (2020) 2003969.
[28] X. Chen, R. Tong, B. Liu, H. Liu, X. Feng, S. Ding, Q. Lei, G. Tang, J. Wu, W. Fang, Biomater. Sci. 8(2019) 1380-1393.
[29] X. Deng, S. Liang, X. Cai, S. Huang, Z. Cheng, Y. Shi, M. Pang, P. Ma, J. Lin, Nano Lett. 19(2019) 6772-6780.
[30] Y. Wan, J. Fang, Y. Wang, J. Sun, Y. Sun, X. Sun, M. Qi, W. Li, C. Li, Y. Zhou, L. Xu, B. Dong, L. Wang, Adv. Healthc. Mater. 10(2021) 2101515.
[31] Q. Wu, M. Niu, X. Chen, L. Tan, C. Fu, X. Ren, J. Ren, L. Li, K. Xu, H. Zhong, Biomaterials 162 (2018) 132-143.
[32] Y. Xiao, M. Xu, N. Lv, C. Cheng, P. Huang, J. Li, Y. Hu, M. Sun, Acta Biomater. 122(2020) 291-305.
[33] H. Ma, Q. Zhou, J. Chang, C. Wu, ACS Nano 13 (2019) 4302-4311.
[34] X.-Z. Zhang, Y.-L. Jiang, J.-G. Hu, L.-M. Zhao, Q.-Z. Chen, Y. Liang, Y. Zhang, X.-X. Lei, R. Wang, Y. Lei, Q.-Y. Zhang, J. Li-Ling, H.-Q. Xie, Bioact. Mater. 6(2021) 1827-1838.
[35] J. Wu, G.R. Williams, S. Niu, F. Gao, R. Tang, L.-M. Zhu, Adv.Sci. 6(2019) 1802001.
[36] X. Fan, Z. Yuan, C. Shou, G. Fan, H. Wang, F. Gao, Y. Rui, K. Xu, P. Yin, Int. J. Nanomed. 14(2019) 9631-9645.
[37] A. Silver, Nature 565 (2019) 123-124.
[38] T.Zhang H.Quan, H. Xu, S.Luo, J. Nie, X. Zhu, Bioact. Mater. 5(2020) 110-115.
[39] D. Chimene, R. Kaunas, A.K. Gaharwar, Adv. Mater. 32(2020) 1902026.
[40] Y. Wang, J. Li, Y. Li, B. Yang, Nano Today 39 (2021) 101180.
[41] J.-W. Xu, K. Yao, Z.-K. Xu, Nanoscale 11 (2019) 8680-8691.
[42] Q.Lu S.Zhang, F. Wang, Z. Xiao, L. He, D. He, L. Deng, ACS Appl. Mater. Interfaces 13 (2021) 37535-37544.
[43] J. Li, Y. Wang, J. Yang, W. Liu, Chem. Eng. J. 420(2020) 127638.