Biocompatibility of Surface-Modified Biphasic Calcium Phosphate/Poly-L-Lactide Biocomposite in vitro and in vivo

J Mater Sci Technol ›› 2010, Vol. 26 ›› Issue (8): 754-758.

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Biocompatibility of Surface-Modified Biphasic Calcium Phosphate/Poly-L-Lactide Biocomposite in vitro and in vivo

Weizhong Yang¹⁾, Guangfu Yin¹⁾, Dali Zhou¹⁾, Jianwen Gu²⁾, Yadong Li²⁾, Hujun Zhang²⁾

1) College of Materials Science and Engineering, Sichuan University, Chengdu 610064, China
2) Chengdu Military General Hospital, Chengdu 610083, China

Received:2009-07-21 Revised:2009-11-17 Online:2010-08-28 Published:2010-08-23
Contact: Jianwen Gu
Supported by:
Doctoral Fund of Ministry of Education of China under grant No. 20060610024

Abstract

Abstract:

The biocompatibility of surface-modified biphasic calcium phosphate (mBCP)/poly-L-Lactide (PLLA) biocomposite was investigated through a series of experiments in vitro and in vivo. Acute toxicity and short term systemic toxicity experiments revealed no toxicity of the materials. Hemolysis assay indicated the good blood compatibility of the composite. In cytotoxicity assay, L929 mouse fibroblasts could well differentiate and proliferate. Animal experiments in vivo were performed by implanting the materials into rabbits muscle for 8 weeks. The decreasing of inflammatory cells, the building of fibrous tissue layer as well as the growing of blood cells into materials indicated the nontoxicity of the composite. Based on the experiment results, surfacemodified BCP/PLLA biocomposite is proven to have superior biocompatibility, which would be a promising bone repairing material.

Key words: Biocompatibility, Biphasic calcium phosphate (BCP), Poly-L-Lactide (PLLA) biocomposite

Weizhong Yang, Guangfu Yin, Dali Zhou, Jianwen Gu, Yadong Li, Hujun Zhang. Biocompatibility of Surface-Modified Biphasic Calcium Phosphate/Poly-L-Lactide Biocomposite in vitro and in vivo[J]. J Mater Sci Technol, 2010, 26(8): 754-758.

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Biocompatibility of Surface-Modified Biphasic Calcium Phosphate/Poly-L-Lactide Biocomposite in vitro and in vivo

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