Abstract: The specific heat of the nanostructured crystals, the glass, the liquid and the crystals for a ZrAINiCuCo alloy has been measured by using the differential scanning calorimeter. The specific heat value and its temperature coefficient of the nanostructured crystals are larger than that of the relaxed glass and of the crystals. Through measuring crystallization enthalpies and specific heat of the alloy in different states, the enthalpy difFerences among the crystals, the liquid and the nanostructured crystals are calculated and the intedece energies of nanostructured crystals are estimated. The stability and the grain size limit of the nanostructured crystals are discussed.