Abstract: Current metallic biomaterials face critical limitations in orthopedic applications, paradoxically exhibiting excessive stiffness alongside incompatible strength-ductility ratios and compromised corrosion resistance. These intrinsic property conflicts fundamentally restrict their clinical applicability despite the urgent demand for multi-property-integrated implants. This work presents a novel (TiZrNb_0.7)₉₈O₂ medium-entropy alloy (MEA) with synergistic integration of high yield strength (σ_y = 1096 MPa), substantial ductility (fracture strain ε_f = 25.1 %), and biomedically favorable modulus (E = 71.4 GPa). The alloy demonstrates a 35.3 % lower elastic modulus compared to conventional Ti6Al4V (110 GPa), effectively mitigating stress-shielding risks. Electrochemical tests in simulated body fluid (PBS, 37 °C) reveal a 0.1556 µA cm^-2 corrosion current density, 1.5-fold lower than Ti6Al4V's 0.2326 µA cm^-2. In vitro cellular assays demonstrated 98.3 % viability of MC3T3-E1 cells following 7-day culture, outperforming Ti6Al4V controls (94.1 %) by 4.2 %. These findings provide valuable insights for designing metal implant materials with excellent properties.

Key words: Medium-entropy alloy, Mechanical properties, Corrosion resistance, Biocompatibility