An organic free radical generator independent on hydrogen peroxide for chemodynamic and immunotherapy in vivo

doi:10.1016/j.jmst.2023.05.079

Abstract

Abstract: It is desirable to develop a free radical generator that is neither dependent on hydrogen peroxide nor external stimuli-triggered to achieve effective tumor treatment. Herein, the free radical generator MNPs-mCPBA was constructed with Zn_0.4Co_0.6F_e2O₄@Zn_0.4Mn_0.6Fe₂O₄ nanoparticles (MNPs) and 3-chloroperbenzoic acid (mCPBA). We believe that the iron (II) on the surface of MNPs-mCPBA maybe represent high reactive activity and promote the generation of a large number of organic free radicals (C₆H₄ClCOOO⋅) in an acidic tumor microenvironment, which realizes the acid-dependent tumor treatment strategy independent on the H₂O₂ level in tumors. In addition, the generated organic free radicals (C₆H₄ClCOOO⋅) effectively induced immunogenic cell death (ICD) and increased T cell infiltration. Under the synergetic treatment with an anti-PD-L1 antibody (α-PD-L1), a favorable anti-tumor effect was achieved.

Key words: Organic free radicals, Immunogenic cell death, Immunotherapy, Chemodynamic therapy

Yang Chen, Yunpeng Song, Chaojie Tang, Hong Yang, Wu Wang, Shiping Yang, Zhiguo Zhou. An organic free radical generator independent on hydrogen peroxide for chemodynamic and immunotherapy in vivo[J]. J. Mater. Sci. Technol., 2024, 174: 85-94.

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