Chemical-NIR dual-powered CuS/Pt nanomotors for tumor hypoxia modulation, deep tumor penetration and augmented synergistic phototherapy

doi:10.1016/j.jmst.2022.10.086

J. Mater. Sci. Technol. ›› 2023, Vol. 148: 171-185.DOI: 10.1016/j.jmst.2022.10.086

• Research article • Previous Articles Next Articles

Chemical-NIR dual-powered CuS/Pt nanomotors for tumor hypoxia modulation, deep tumor penetration and augmented synergistic phototherapy

Wenjun Wang^a,1, Enhui Ma^b,1, Pengyu Tao^a,1, Xiaoyu Zhou^a, Yujuan Xing^a, Liang Chen^a, Yingying Zhang^a, Jingjing Li, Kai Xu^a,c,*, Hong Wang^b,*, Shaohui Zheng^a,c,*

^aSchool of Medical Imaging, Xuzhou Medical University, Xuzhou 221006, China;
^bSchool of Chemical Engineering & Technology, China University of Mining and Technology, Xuzhou 221116, China;
^cDepartment of Radiology, Affiliated Hospital of Xuzhou Medical University, Xuzhou 221004, China

Received:2022-09-02 Revised:2022-10-06 Accepted:2022-10-13 Published:2023-06-10 Online:2023-06-05
Contact: *E-mail addresses:. xkpaper@163.com (K. Xu), hongwang@cumt.edu.cn (H. Wang), shaohui19910@163.com (S. Zheng)
About author:¹These authors contributed equally to this work.

Abstract

Abstract: The complex tumor microenvironment (TME) with the characteristics of severe hypoxia, enriched hydrogen peroxide (H₂O₂) and dense nature significantly restricted the therapeutic efficacy of nanomedicine in cancer treatment. Synthetic micro/nanomotors have shown multiple versatility in modulating the abnormal TME and overcoming the limited penetration in solid tumor. Herein, we constructed a chemical-NIR dual-propelled nanomotor based on CuS/Pt Janus nanoparticles with IR820 encapsulation for hypoxia alleviation, deep tumor penetration and augmented synergistic photodynamic (PDT) and photothermal therapy (PTT). The deposited Pt effectively catalyzed tumor endogenous H₂O₂ into oxygen, which extremely relieved the tumor hypoxia state and allowed the chemical propulsion of nanomotors. Under NIR irradiation, the Janus nanomotors exhibited more obvious movement via efficient photothermal conversion. Such autonomous motion significantly improved the tumoral accumulation of nanomotors and facilitated much deeper penetration inside tumor in vivo. In addition, enriched oxygen also promoted the generation of reactive oxygen species (ROS) for augment of PDT, which achieved satisfied antitumor effect in combination with the PTT treatment. Therefore, this strategy based on CuS/Pt Janus nanomotors would provide an innovative dimension for considerable applications in effective cancer management.

Key words: CuS/Pt Janus nanomotors, Chemical-NIR dual-propulsion, Deep tumor penetration, Hypoxia alleviation, Synergistic PDT and PTT

Wenjun Wang, Enhui Ma, Pengyu Tao, Xiaoyu Zhou, Yujuan Xing, Liang Chen, Yingying Zhang, Jingjing Li, Kai Xu, Hong Wang, Shaohui Zheng. Chemical-NIR dual-powered CuS/Pt nanomotors for tumor hypoxia modulation, deep tumor penetration and augmented synergistic phototherapy[J]. J. Mater. Sci. Technol., 2023, 148: 171-185.

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Chemical-NIR dual-powered CuS/Pt nanomotors for tumor hypoxia modulation, deep tumor penetration and augmented synergistic phototherapy

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