Sol-gel Preparation and Preliminary in vitro Evaluationof Fluorapatite/Hydroxyapatite Solid Solution Films

Abstract

Abstract: Fluorapatite/hydroxyapatite solid solution has better biological properties than other apatites, especially used as films or coatings. In this work, sol-gel preparation and in vitro behavior of fluorapatite/hydroxyapatite solid solution films on titanium alloy were investigated. Ca(NO3)2·4H22O and PO(OH)x(OEt)3-x were selected as precursors, and hexafluorophosphoric acid (HPF6) was used as a fluorine containing reagent. The Ca and P precursors were mixed with HPF6 to keep the Ca/P molar ratio 1.67. The mixtures refluxed for 12 h were used as dipping sols for the preparation of the films. The phase of the films obtained at 600°C was apatite. The F contents in the films increased with the concentrations of HPF6 in the dipping sols. The solid solution films were shown to have better stability than hydroxyapatite films, and a reasonably good bioactivity in the in vitro evaluation.

Key words: Fluorapatite/Hydroxyapatite, Sol-gel, Hexafluorophosphoric acid, Film

Chenlu SONG, Wenjian WENG, Kui CHENG, Haibo QU, Piyi DU, Ge SHEN, Gaorong HAN, Juan YANG, Jose M.F.Ferreira. Sol-gel Preparation and Preliminary in vitro Evaluationof Fluorapatite/Hydroxyapatite Solid Solution Films[J]. J Mater Sci Technol, 2003, 19(05): 495-499.

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