Abstract: Oxidative stress is a critical risk factor for various disease complications in patients with end-stage renal disease, which may be further aggravated during hemodialysis. Herein, we prepared a hemodialysis membrane by introducing poly (2-Acrylamide-2-methylpropanesulfonic acid-N-vinylpyrrolidone) (P(AMPS-VP)) into the polyethersulfone (PES) membrane by simple in-situ polymerization and non-solvent phase separation (NIPS) method, followed by tannic acid (TA) coating construction through hydrogen bonding interaction, termed PES/P(AMPS-VP)-TA. The membrane can efficiently remove reactive nitrogen radicals (RNS) (DPPH•, 89.96 %; ABTS•⁺, 90.49 %) and reactive oxygen species (ROS) (O₂•^-, 90.45 %), and has a very stable antioxidant property. Meanwhile, the membrane does not cause hemolysis and coagulation, and has superior blood compatibility required by hemodialysis membrane. In addition, the dialysis performance of the membrane is improved compared with unmodified PES, which is beneficial for practical hemodialysis applications. This work provides a reference for industrial preparation of hemodialysis membranes, which is expected to be applied to reduce oxidative stress in hemodialysis patients.

Key words: In-situ polymerization, Oxidative stress, Anticoagulation, Hemodialysis membrane