Spreadable thermosensitive nanocomposite hydrogel dressing with ultrasound-responsive bactericidal/repair-promoting regulation and cascade antioxidantion for infected burn wound repair

doi:10.1016/j.jmst.2024.08.054

J. Mater. Sci. Technol. ›› 2025, Vol. 219: 189-204.DOI: 10.1016/j.jmst.2024.08.054

• Research article • Previous Articles Next Articles

Spreadable thermosensitive nanocomposite hydrogel dressing with ultrasound-responsive bactericidal/repair-promoting regulation and cascade antioxidantion for infected burn wound repair

Meng Yu^a,1, Yi Guo^b,1, Shaowen Zhou^c,1, Yanhuai Li^a, Zexing Deng^d,e,*, Xin Zhao^a,*, Yong Han^a,f,*

^aState Key Laboratory for Mechanical Behavior of Materials, Xi’an Jiaotong University, Xi’an 710049, China
^bShaanxi Key Laboratory of Brain Disorders, Institute of Basic and Translational Medicine, Xi’an Medical University, Xi’an 710021, China
^cKey Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi’an Jiaotong University, Xi’an 710049, China
^dCollege of Materials Science and Engineering, Xi’an University of Science and Technology, Xi’an 710054, China
^eDepartment of Radiology, Functional and Molecular Imaging Key Lab of Shaanxi Province, Tangdu Hospital, Air Force Medical University, Xi’an 710038, China
^fDepartment of Orthopaedics, The First Affiliated Hospital College of Medicine, Xi’an Jiaotong University, Xi’an 710061, China

Received:2024-07-23 Revised:2024-08-23 Accepted:2024-08-29 Published:2024-09-20 Online:2025-06-05
Contact: *E-mail addresses:biomaterial@xust.edu.cn (Z. Deng),zhaoxinbio@mail.xjtu.edu.cn (X. Zhao),yonghan@mail.xjtu.edu.cn (Y. Han)
About author:¹These authors contributed equally to this work.

Abstract

Abstract: Treating severe burn wounds poses significant challenges, including considerable cell loss, excessive inflammation, and a high susceptibility to bacterial infections. Ideal burn dressings should exhibit excellent antibacterial properties, anti-inflammatory effects, and promote cell proliferation. Additionally, they need facilitate painless dressing changes and be user-friendly. Herein, we synthesized a thermosensitive hydrogel by crosslinking poly (N-isopropylacrylamide-co-allyloxybenzaldehyde) (PNA) and amino-terminated Pluronic F127 (APF) through a Schiff base reaction. It exhibited reversible gel-sol transition and spreadability. By incorporating piezoelectric gold nanoparticle-modified barium titanate (Au@BaTiO₃) and cascade antioxidant MOF-818, a nanocomposite hydrogel dressing with diverse bioactive functionalities was developed. Results demonstrated that the nanocomposite hydrogel possessed gel-sol transition properties, maintained a stable gel state within a broad temperature range, and desirable self-healing property. Au@BaTiO₃ exhibited good piezoelectric properties and ROS generation upon ultrasound stimulation, while MOF-818 displayed highly efficient cascade nanozyme activity. The combination of Au@BaTiO₃ and MOF-818 promoted fibroblast proliferation and migration, reduced intracellular ROS levels, and induced anti-inflammatory polarization of macrophages under ultrasound stimulation. In vitro and in vivo antibacterial results disclosed that the nanocomposite hydrogel had excellent antibacterial activity under high-intensity ultrasound stimulation. When applied to infected burn wounds, the nanocomposite hydrogel can rapidly sterilize the wound upon initial high-intensity ultrasound, and then reduce inflammation and promote M2 macrophage polarization by the following low-intensity ultrasound stimulation, and thus accelerating the healing by improving granulation tissue formation, angiogenesis, and collagen deposition.

Key words: Thermosensitive nanocomposite hydrogel, Piezoelectric nanoparticles, MOF nanozyme, Bactericidal/repair-promoting regulation, Infected burn wound

Meng Yu, Yi Guo, Shaowen Zhou, Yanhuai Li, Zexing Deng, Xin Zhao, Yong Han. Spreadable thermosensitive nanocomposite hydrogel dressing with ultrasound-responsive bactericidal/repair-promoting regulation and cascade antioxidantion for infected burn wound repair[J]. J. Mater. Sci. Technol., 2025, 219: 189-204.

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Spreadable thermosensitive nanocomposite hydrogel dressing with ultrasound-responsive bactericidal/repair-promoting regulation and cascade antioxidantion for infected burn wound repair

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