J. Mater. Sci. Technol. ›› 2012, Vol. 28 ›› Issue (3): 261-267.

• Reviews • 上一篇    下一篇

In Vivo and In Vitro Degradation Behavior of Magnesium Alloys as Biomaterials

Dingchuan Xue1,Yeoheung YunZongqing TanZhongyun DongMark Schulz   

  • 收稿日期:2011-07-14 修回日期:2011-09-26 出版日期:2012-03-31 发布日期:2012-03-31
  • 通讯作者: Dingchuan Xue

In Vivo and In Vitro Degradation Behavior of Magnesium Alloys as Biomaterials

Dingchuan Xue1), Yeoheung Yun2), Zongqing Tan3), Zhongyun Dong3), Mark J. Schulz4)   

  1. 1) Department of Chemical and Materials Engineering, University of Cincinnati, OH 45221, USA
    2) Department of Bioengineering, North Carolina A & T State University, Greensboro, NC 27411, USA
    3) Department of Internal Medicine, University of Cincinnati, OH 45221, USA
    4) Department of Mechanical Engineering, University of Cincinnati, OH 45221, USA
  • Received:2011-07-14 Revised:2011-09-26 Online:2012-03-31 Published:2012-03-31
  • Contact: Dingchuan Xue

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摘要： The corrosion behavior of pure Mg, AZ31, and AZ91D were evaluated in various In Vitro and In Vivo environments to investigate their potential application of being biomaterials. DC polarization test and immersion test were performed in different simulated body solutions, such as DI water, Simulated Body Fluid (SBF) and Phosphate Buffered Solution (PBS). The Mg/Mg alloys were further implanted into different places in the mouse body for In Vivo weight loss and biocompatibility investigations. In Vivo subcutis bio-corrosion rate was lower than all of the In Vivo simulated corrosive environment. The Mg/Mg alloys did not introduce the biocompatibility issues as the histology results showed in liver, heart, kidney, skin and lung of the mouse during a two months implantation. Optical microscope and SEM were carried out to investigate the morphology and topography of Mg/Mg alloys after immersion test and implantation in order to understand the corrosion mechanisms.

Abstract: The corrosion behavior of pure Mg, AZ31, and AZ91D were evaluated in various in vitro and in vivo environments to investigate the potential application of these metals as biodegradable implant materials. DC polarization tests and immersion tests were performed in different simulated body solutions, such as distilled (DI) water, simulated body fluid (SBF) and phosphate buffered solution (PBS). Mg/Mg alloys were also implanted in different places in a mouse for in vivo weight loss and biocompatibility investigations. The in vivo subcutis bio-corrosion rate was lower than the corrosion rate for all of the in vitro simulated corrosive environments. The Mg/Mg alloys were biocompatible based on histology results for the liver, heart, kidney, skin and lung of the mouse during the two months implantation. Optical microscopy and scanning electron microscopy were carried out to investigate the morphology and topography of Mg/Mg alloys after immersion testing and implantation to understand the corrosion mechanisms.

Key words: Mg/Mg alloys, In vitro/in vivo testing, Bio-degradation rate, Biocompatibility