Processing of a Novel Zn Alloy Micro-Tube for Biodegradable Vascular Stent Application

doi:10.1016/j.jmst.2016.08.008

材料科学与技术 ›› 2016, Vol. 32 ›› Issue (9): 925-929.DOI: 10.1016/j.jmst.2016.08.008

收稿日期:2015-09-29 接受日期:2015-12-12 出版日期:2016-09-20 发布日期:2016-11-02

Processing of a Novel Zn Alloy Micro-Tube for Biodegradable Vascular Stent Application

Wang Chang¹,Yu Zhentao^1,^*(),Cui Yajun^1,²,Zhang Yafeng¹,Yu Sen¹,Qu Gongqi³,Gong Haibo³

¹ Northwest Institute for Nonferrous Metal Research, Xi'an 710016, China
² Xi'an University of Architecture and Technology, Xi'an 710055, China
³ Xi'an Advanced Medical Technology Co., Ltd., Xi'an 710077, China

Received:2015-09-29 Accepted:2015-12-12 Online:2016-09-20 Published:2016-11-02
Contact: Yu Zhentao

摘要/Abstract

Abstract:

In recent years, zinc based alloys as a new biodegradable metal material aroused intensive interests. However, the processing of Zn alloys micro-tubes (named slender-diameter and thin-walled tubes) is very difficult due to their HCP crystal structure and unfavorable mechanical properties. This study aimed to develop a novel technique to produce micro-tube of Zn alloy with good performance for biodegradable vascular stent application. In the present work, a processing method that combined drilling, cold rolling and optimized drawing was proposed to produce the novel Zn-5Mg-1Fe (wt%) alloy micro-tubes. The micro-tube with outer diameter of 2.5?mm and thickness of 130?μm was fabricated by this method and its dimension errors are within 10?μm. The micro-tube exhibits a fine and homogeneous microstructure, and the ultimate tensile strength and ductility are more than 220?MPa and 20% respectively. In addition, the micro-tube and stents of Zn alloy exhibit superior in vitro corrosion and expansion performance. It could be concluded that the novel Zn alloy micro-tube fabricated by above method might be a promising candidate material for biodegradable stent.

Key words: Zn alloy, Micro-tube, Biodegradable stent, Mechanical properties, Dimensional accuracy, In vitro corrosion performance

. [J]. 材料科学与技术, 2016, 32(9): 925-929.

Wang Chang,Yu Zhentao,Cui Yajun,Zhang Yafeng,Yu Sen,Qu Gongqi,Gong Haibo. Processing of a Novel Zn Alloy Micro-Tube for Biodegradable Vascular Stent Application[J]. J. Mater. Sci. Technol., 2016, 32(9): 925-929.

图/表 9

Table 1 Typical different drawing conditions of Zn alloy micro-tubes

No.	Drawing method	R/P	DP	Lubricant
1	HS/ MD	25%	1	Oil
2	HS/ MD	15%	1	Oil
3	HS	7%	3	Oil
4	HS	4%	5	Oil
5	HS	2%	10	Oil
6	HS	4%	5	MoS2
7	MD	<15%	2	Oil

Fig. 1. Schematic diagrams of hollow sinking and mandrel drawing.

Table 2 Mechanical properties of Zn alloy micro-tubes with different drawing conditions

No.	Drawing possibility	UTS (MPa)	YS (MPa)	Elongation (%)
1	Brittle failure	-	-	-
2	Surface flaw	-	-	-
3	Feasible	180-186	151-158	12-18
4	Feasible	211-218	174-186	16-21
5	Feasible	189-197	154-163	7-11
6	Feasible	184-193	122-134	5-8
7	Feasible	223-231	176-187	22-26

Fig. 2. Zn alloy tubes: (a) from drilled tubes to micro-tubes; (b-c) 3.0?mm rolled micro-tube; (d-e) 2.5?mm drawn micro-tube.

Fig. 3. Dimensional accuracy of the drawn Zn alloy micro-tubes (ф 2.5?mm?×?130?μm).

Fig. 4. Microstructure of the Zn alloy tubes: (a-b) drilled tubes; (c-d) 3.0?mm rolled micro-tube; (e-f) 2.5?mm drawn micro-tube; (g-h) 2.5?mm drawn tube after annealing.

Fig. 5. Morphology of the micro-tubes after immersion test: (a) rolled Zn alloy; (b) drawn Zn alloy; (c) drawn AZ31 alloy.

Fig. 6. Weight loss percentage of Zn alloy micro-tubes during immersion test.

Fig. 7. Zn alloy stent: (a) after polishing; (b) crimped into 1.3?mm; (c) expanded into 3.5?mm.

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