Electrospinning nanofiber scaffolds for soft and hard tissue regeneration

Xianrui Xie^a, Yujie Chen^a^,^*, Xiaoyu Wang^a, Xiaoqing Xu^a, Yihong Shen^a, Atta ur Rehman Khan^a, Ali Aldalbahi^b^,^*(

), Allison E. Fetz^c, Gary L. Bowlin^c, Mohamed El-Newehy^b, Xiumei Mo^a^,^*(

)

Fig. 6.. Schematic of how a scaffold structure affects cell adhesion and spreading [32]. (A), (B) Cells adhere in a flat morphology on the microporous and microfiber scaffolds, similar to that observed on flat surfaces. (C) Nanofibers have a greater surface area, and therefore adsorbed more protein, providing more adhesion sites for cell membrane receptors.