Electrospinning nanofiber scaffolds for soft and hard tissue regeneration

Xianrui Xie^a, Yujie Chen^a^,^*, Xiaoyu Wang^a, Xiaoqing Xu^a, Yihong Shen^a, Atta ur Rehman Khan^a, Ali Aldalbahi^b^,^*(

), Allison E. Fetz^c, Gary L. Bowlin^c, Mohamed El-Newehy^b, Xiumei Mo^a^,^*(

)

Fig. 24.. (A) Composite scaffold preparation. Dual electrospinning was employed to fabricate a scaffold containing PCL and methacrylated gelatin (mGLT) fibers (Insert 1). The dry scaffold was wetted with an aqueous photo-initiator solution (Insert 2) and then photo-crosslinked by visible light to retain the gelatin (Insert 3). (B) Scaffold sheets were wetted, stacked, and exposed to visible light for crosslink formation between adjacent scaffold layers to create a complex multi-layered structure [90].