Electrospinning nanofiber scaffolds for soft and hard tissue regeneration

Xianrui Xie^a, Yujie Chen^a^,^*, Xiaoyu Wang^a, Xiaoqing Xu^a, Yihong Shen^a, Atta ur Rehman Khan^a, Ali Aldalbahi^b^,^*(

), Allison E. Fetz^c, Gary L. Bowlin^c, Mohamed El-Newehy^b, Xiumei Mo^a^,^*(

)

Fig. 19.. Macroscopic images (a, d, and g) of the cartilage joints from the non-treated group, group treated with the non-functionalized scaffold (3DS-1), and the group treated with the hyaluronic acid-functionalized scaffold (3DS-2) at 12 weeks after surgery. Histological analysis of the cartilage defect area from the three groups, stained with Safranin O-fast green (b, e, and h) and H&E (c, f, and i), indicate that the functionalized scaffold enhanced repair. Arrows and dotted lines indicated the defect sites. OC: original cartilage tissue. RC: repaired cartilage tissue [83].