Electrospinning nanofiber scaffolds for soft and hard tissue regeneration

Xianrui Xie^a, Yujie Chen^a^,^*, Xiaoyu Wang^a, Xiaoqing Xu^a, Yihong Shen^a, Atta ur Rehman Khan^a, Ali Aldalbahi^b^,^*(

), Allison E. Fetz^c, Gary L. Bowlin^c, Mohamed El-Newehy^b, Xiumei Mo^a^,^*(

)

Fig. 18.. Electrospun silk fibroin nanofibrous scaffolds engineered with two-stage hydroxyapatite (HA) particle functionalization. These scaffolds were found to support the osteogenic differentiation of genetically-modified human adipose-derived mesenchymal stem cells after 21 days in vitro and enhance mineralized bone formation and collagen deposition in vivo in a critical-sized calvarial bone defect after 8 weeks [79].