Electrospinning nanofiber scaffolds for soft and hard tissue regeneration

Xianrui Xie^a, Yujie Chen^a^,^*, Xiaoyu Wang^a, Xiaoqing Xu^a, Yihong Shen^a, Atta ur Rehman Khan^a, Ali Aldalbahi^b^,^*(

), Allison E. Fetz^c, Gary L. Bowlin^c, Mohamed El-Newehy^b, Xiumei Mo^a^,^*(

)

Fig. 17.. Design of an scaffold containing MSN and alendronate (ALN) for the dual delivery of ALN and silicate to modulate bone resorption and formation for accelerating bone repair. The ALN pre-loaded within the MSNs is released from the nano?bers and inhibits the bone-resorption process by preventing GTP-related protein expression. The silicate produced by the hydrolysis of MSNs is released from the nano?bers and promotes the bone-forming process by improving vascularization and bone calci?cation [77].