.

Fig. 3.. Shear-sensitive mechano-active drug delivery systems. (a) Shear-sensitive lenticular vesicles made from an artificial 1,3-diaminophospholipid which are stable under static conditions but release their contents at elevated shear stress via preferential breaking points along the vesicle’s equator (reprinted with permission from [32]). (b) Microaggregates of nanoparticles (large spheres) remain intact in the pre-stenotic region, but then disintegrate into nanoparticles (small spheres) when they flow through a constriction and accumulate in the endothelial cells (reprinted with permission from [33]); (c) A hydrogel with a shear-mediated release of anti-TNFα (reprinted with permission from [35]).