.

Fig. 2.. Strain-sensitive mechano-active drug delivery systems. (a) Hyaluronic acid hydrogels with a compression-modulated dexamethasone release capacity (reprinted with permission from [23]); (b) A hydrogel trapped with drug-loaded liposomes, which releases drugs through the rupture of the liposomes under proper level of stress (reprinted with permission from [24]); (c) Stretching-triggered drug release from the nanoparticles into microdepots on an elastomeric substrate (reprinted with permission from [26]); (d) Crack development in the superhydrophobic barrier coating on a hydrophilic mesh core when stretched (reprinted with permission from [27]); (e) A ceramic-starch composite sponge (CCS) with a hierarchically porous structure, demonstrating a mechano-active delivery of molecules and cells with high precision (reprinted with permission from [30]).