Multifunctional metal-polyphenol nanocomposite for melanoma targeted photo/chemodynamic synergistic therapy

doi:10.1016/j.jmst.2022.12.039

Abstract

Abstract: Due to the hypoxic state of the tumor microenvironment (TME), photodynamic therapy (PDT) suffers from insufficient ROS production. The metal-polyphenol network-mediated Fenton reaction can generate reactive oxygen species (ROS) by consuming H₂O₂ in TME, improving the inadequate ROS generation problem of PDT. Therefore, synergistic therapy combining PDT and Fenton response-based CDT is a promising approach for cancer treatment. Herein, a metal-polyphenol nanocomposite was deposited with gallic acid grafted hyaluronic acid and Fe³⁺ to contrast a Ce6 nano-delivery system (Ce6@HSF NPs) for melanoma synergistic therapy. Ce6@HSF NPs could be used as a Fenton reagent to induce the ·OH production and enhance the PDT effect of Ce6 to a certain extent. After 4 h of cellular uptake, the fluorescence intensity of Ce6 in the Ce6@HSF NPs group was higher than 3 times that in the Ce6 group. The intracellular ROS generation level of the Ce6@HSF NPs (L) group combining CDT and PDT was higher than that of the Ce6 group and Ce6@HSF NPs group. In vitro and in vivo anti-melanoma studies show that Ce6@HSFNPs (L) group exhibited better anti-melanoma than other groups. Together, Ce6@HSF NPs provide a promising synergistic treatment potential for melanoma.

Key words: Photodynamic therapy, Chemodynamic therapy, Fenton reaction, Metal-polyphenol network

Di Chuan, Huan Hou, Yuelong Wang, Min Mu, Jinglun Li, Yangmei Ren, Na Zhao, Bo Han, Haifeng Chen, Gang Guo. Multifunctional metal-polyphenol nanocomposite for melanoma targeted photo/chemodynamic synergistic therapy[J]. J. Mater. Sci. Technol., 2023, 152: 159-168.

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