J. Mater. Sci. Technol. ›› 2018, Vol. 34 ›› Issue (6): 1054-1059.DOI: 10.1016/j.jmst.2017.07.009

Special Issue: Biomaterials 2018

• Orginal Article • Previous Articles    

Hydrothermal growth of whitlockite coating on β-tricalcium phosphate surfaces for enhancing bone repair potential

Xiaoheng Guoab,1, Xiao Liuab,1, Huichang Gaod, Xuetao Shiab, Naru Zhaoac*(), Yingjun Wangab*()   

  1. aSchool of Materials Science and Engineering, South China University of Technology, Guangzhou 510641, China
    bNational Engineering Research Centre for Tissue Restoration and Reconstruction, Guangzhou 510006, China
    cGuangdong Province Key Laboratory of Biomedical Engineering, South China University of Technology, Guangzhou 510006, China
    dSchool of Medicine, South China University of Technology, Guangzhou 510006, China
  • Received:2017-02-18 Revised:2017-05-12 Accepted:2017-06-09 Online:2018-06-10 Published:2018-06-05
  • Contact: Zhao Naru,Wang Yingjun

Abstract:

In this study, we developed a simple approach for the controllable growth of whitlockite (WH) on a β-tricalcium phosphate surface and investigated its cell viability via CCK-8, its live-dead staining and its alkaline phosphatase activity. Herein, WH with controllable morphologies was prepared by regulating the hydrothermal reaction conditions. The results of scanning electron microscopy, X-ray diffraction and X-ray photoelectron spectroscopy indicated that pure hexagonal plates of WH were prepared successfully. In vitro cell experiments showed that WH possessed excellent biocompatibility and effectively promoted the adhesion and proliferation of mouse bone mesenchymal stem cells. The osteogenesis of the WH was also enhanced. The obtained WH was expected to be utilized for promising applications as implantable block materials for bone repair.

Key words: Surface, Whitlockite, Hydrothermal reaction, Bone repair