Microstructure, Mechanical Properties and In Vitro Degradation Behavior of a Novel Biodegradable Mg-1.5Zn-0.6Zr-0.2Sc Alloy

doi:10.1016/j.jmst.2015.02.001

Abstract

Abstract: A novel Mg-1.5Zn-0.6Zr-0.2Sc (denoted as ZK21-0.2Sc) alloy was developed as potential biodegradable implant materials. The microstructure, mechanical properties, and in vitro degradation behavior of the as-cast ZK21-0.2Sc alloy were investigated and compared with ZK21 alloy and pure Mg. The ZK21-0.2Sc alloy showed a single-phase structure with fine equiaxed grains. The alloy exhibited a good balance between strength and ductility. Both immersion tests and electrochemical tests showed that the ZK21-0.2Sc alloy had the lowest degradation rate in Hank's solution. The excellent degradation behavior of ZK21-0.2Sc alloy could be explained by the single-phase and fine grain structure, the more effective protection corrosion film, and the beneficial alloying effects of Zn, Zr and Sc.

Key words: Magnesium alloys, Scandium, Biomaterials, Biodegradable, Corrosion

Tao Li, Hailong Zhang, Yong He, Ning Wen, Xitao Wang. Microstructure, Mechanical Properties and In Vitro Degradation Behavior of a Novel Biodegradable Mg-1.5Zn-0.6Zr-0.2Sc Alloy[J]. J. Mater. Sci. Technol., 2015, 31(7): 744-750.

Figures/Tables 12

XRD patterns of as-cast ZK21, ZK21-0.2Sc and pure Mg.

Optical microstructures of as-cast ZK21, ZK21-0.2Sc and pure Mg.

Tensile properties of as-cast ZK21, ZK21-0.2Sc and pure Mg at room temperature.

Hydrogen evolution volumes of as-cast ZK21, ZK21-0.2Sc and pure Mg as a function of immersion time in Hank's solution.

pH values of Hank's solutions for as-cast ZK21, ZK21-0.2Sc and pure Mg as a function of immersion time.

Mg ion concentrations in the Hank's solutions of as-cast ZK21, ZK21-0.2Sc and pure Mg after immersion tests (The concentrations of released Zn, Zr and Sc ions were well below the minimum detection limits of ICP-OES.).

Surface morphologies of degradation products on as-cast ZK21, ZK21-0.2Sc and pure Mg after immersion in Hank's solution at 37 °

C for 168 h: (a, b) ZK21, (c, d) ZK21-0.2Sc, (e, f) pure Mg.

Corroded surface morphologies of as-cast ZK21, ZK21-0.2Sc and pure Mg with degradation products removed after immersion in Hank's solution at 37 °

C for 168 h: (a) ZK21, (b) ZK21-0.2Sc, (c) pure Mg.

Degradation rates of as-cast ZK21, ZK21-0.2Sc and pure Mg concluded by mass loss after immersion in Hank's solution at 37 °

C for 168 h.

References

[1] Y.F. Zheng, X.N. Gu, F. Witte, Mater. Sci. Eng. R , 77 (2014), pp. 1-34
[2] Y. Chen, Z. Xu, C. Smith, J. Sankar, Acta Biomater. , 10 (2014), pp. 4561-4573
[3] F. Witte, V. Kaese, H. Haferkamp, E. Switzer, A. Meyer-Lindenberg, C.J. Wirth, H. Windhagen, Biomaterials , 26 (2005), pp. 3557-3563
[4] X. Gu, Y. Zheng, Y. Cheng, S. Zhong, T. Xi, Biomaterials , 30 (2009), pp. 484-498
[5] N. Li, Y. Zheng, J. Mater. Sci. Technol. , 29 (2013), pp. 489-502
[6] L. Tan, X. Yu, P. Wan, K. Yang, J. Mater. Sci. Technol. , 29 (2013), pp. 503-513
[7] Y. Lu, L. Tan, H. Xiang, B. Zhang, K. Yang, Y. Li, J. Mater. Sci. Technol. , 28 (2012), pp. 636-641
[8] R.C. Zeng, L. Sun, Y.F. Zheng, H.Z. Cui, E.H. Han, Corros. Sci. , 79 (2014), pp. 69-82
[9] X. Lin, L. Tan, Q. Zhang, K. Yang, Z. Hu, J. Qiu, Y. Cai, Acta Biomater. , 9 (2013), pp. 8631-8642
[10] L. Mao, G. Yuan, J. Niu, Y. Zong, W. Ding, Mater. Sci. Eng. C , 33 (2013), pp. 242-250
[11] D. Liu, Y. Zuo, W. Meng, M. Chen, Z. Fan, Mater. Sci. Eng. C , 32 (2012), pp. 1253-1258
[12] R.K. Gupta, K. Mensah-Darkwa, D. Kumar, J. Mater. Sci. Technol. , 30 (2014), pp. 47-53
[13] R.C. Zeng, F. Zhang, Z.D. Lan, H.Z. Cui, E.H. Han, Corros. Sci. , 88 (2014), pp. 452-459
[14] Y. Xin, T. Hu, P.K. Chu, Acta Biomater. , 7 (2011), pp. 1452-1459
[15] J.F. King, H.E. Friedrich, B.L. Mordike (Eds.), Magnesium Technology: Metallurgy, Design Data, Applications, Springer, Berlin (2006), p. 266
[16] X. Ye, M. Chen, M. Yang, J. Wei, D. Liu, J. Mater. Sci. Mater. Med. , 21 (2010), pp. 1321-1328
[17] R. Arrabal, A. Pardo, M.C. Merino, M. Mohedano, P. Casajús, K. Paucar, G. Garcés, Corros. Sci. , 55 (2012), pp. 301-312
[18] F. Witte, N. Hort, C. Vogt, S. Cohen, K.U. Kainer, R. Willumeit, F. Feyerabend, Curr. Opin. Solid State Mater. Sci. , 12 (2008), pp. 63-72
[19] B. Venugopal, T.D. Luckey, Metal Toxicity in Mammals, Plenum Press, New York (1977)
[20] H.S. Brar, J.P. Ball, I.S. Berglund, J.B. Allen, M.V. Manuel, Acta Biomater., 9 (2013), pp. 5331-5340
[21] F. Feyerabend, J. Fischer, J. Holtz, F. Witte, R. Willumeit, H. Drücker, C. Vogt, N. Hort, Acta Biomater. , 6 (2010), pp. 1834-1842
[22] ASTM G31-72, Standard Practice for Laboratory Immersion Corrosion Testing of Metals, American Society for Testing & Materials, West Conshohocken (2004)
[23] T. Li, Y. He, H. Zhang, X. Wang, J. Magnesium Alloys , 2 (2014), pp. 181-189
[24] ISO 10993-4, Biological Evaluation of Medical Devices, Part 4: Selection of Tests for Interactions with Blood, ANSI/AAMI, Arlington, VA (2002)
[25] E. Zhang, L. Yang, J. Xu, H. Chen, Acta Biomater. , 6 (2010), pp. 1756-1762
[26] H.R.B. Rad, M.H. Idris, M.R.A. Kadir, S. Farahany, Mater. Des. , 33 (2012), pp. 88-97
[27] F. Zucchi, V. Grassi, A. Frignani, C. Monticelli, G. Trabanelli, J. Appl. Electrochem. , 36 (2006), pp. 195-204
[28] S. Zhang, J. Li, Y. Song, C. Zhao, X. Zhang, C. Xie, Y. Zhang, H. Tao, Y. He, Y. Jiang, Y. Bian, Mater. Sci. Eng. C , 29 (2009), pp. 1907-1912
[29] T. Li, H. Zhang, Y. He, X. Wang, Mater. Corros. , 66 (2015), pp. 7-15
[30] D. Hong, P. Saha, D.-T. Chou, B. Lee, B.E. Collins, Z. Tan, Z. Dong, P.N. Kumta, Acta Biomater. , 9 (2013), pp. 8534-8547
[31] J. Niu, G. Yuan, Y. Liao, L. Mao, J. Zhang, Y. Wang, F. Huang, Y. Jiang, Y. He, W. Ding, Mater. Sci. Eng. C , 33 (2013), pp. 4833-4841